Home > Lymph nodes & spleen, nonlymphoma
Lymph nodes & spleen, nonlymphoma

Authors: Nadine Aguilera, M.D., Roaa Aljuaid, M.B.B.S., Ahmed Alrajjal, M.D., João Víctor Alves de Castro, M.D., Barina Aqil, M.D., Aaron Auerbach, M.D., M.P.H., Simon A. Backer, M.D., Jayalakshmi Balakrishna, M.D., Amy Beckman, M.D., Jacob Bledsoe, M.D., Laura Brown, M.D., Ryanne A. Brown, M.D., M.B.A., Elizabeth Courville, M.D., Genevieve M. Crane, M.D., Ph.D., David Danielson, M.D., William D. DePond, M.D., April Ewton, M.D., Julie Feldstein, M.D., Ali Gabali, M.D., Ph.D., Jennifer B. Gordetsky, M.D., Elaine S. Jaffe, M.D., Keri Janowiak, M.D., M.Ed., Rick Kapur, M.D., Ph.D., M.Sc., Sumire Kitahara, M.D., Sajna V.M. Kutty, M.D., David Lynch, M.D., Jaleh Mansouri, M.D., M.P.H., Mario L. Marques-Piubelli, M.D., Roberto N. Miranda, M.D., Hina Mohsin, M.D., Pichayut Nithagon, M.D., Robert S. Ohgami, M.D., Ph.D., Ekene Okoye, M.D., Zenggang Pan, M.D., Ph.D., Nat Pernick, M.D., Olga Pozdnyakova, M.D., Ph.D., Aishwarya Ravindran, M.D., Karen L. Rech, M.D., Jack Reid, M.D., Sherif A. Rezk, M.D., Mina Sabet, M.D., Valentina Sangiorgio, M.D., Nikhil Sangle, M.D., John Schmieg, M.D., Ph.D., Roman Segura-Rivera, M.D., Vijay Shankar, M.D., Vignesh Shanmugam, M.D., Abdelsalam Sharabi, M.D., Kunwar Singh, M.D., Ingrid Tam, M.D., M.Sc., Emina Emilia Torlakovic, M.D., Ph.D., Patricia Tsang, M.D., M.B.A., Tayler A. van den Akker, M.D., Jayalakshmi Venkateswaran, M.D., Leonard Nsoyori Yenwongfai, M.D., M.S., Sheren Younes, M.D., Ph.D., Selveras Zayed, M.B.B.Ch., B.A.O.

Last staff update: 5 November 2024

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Editorial Board oversight: Patricia Tsang, M.D., M.B.A. (last reviewed May 2024), Elizabeth Courville, M.D. (last reviewed December 2022)
Table of contents
Lymph nodes-general:anatomy & histology-lymph nodes B & T cells books grossing & features to report-lymph nodes WHO system for reporting lymph node cytopathology (pending)
Ectopic tissue / inclusions:adipose tissue decidual reaction epithelial inclusions mesothelial inclusions other ectopic tissue / inclusions
Pigment / foreign material:anthracosis lipofuscin silicone other pigment / foreign material
Lymph nodes-infectious / parasitic disorders:cat scratch disease HIV infectious mononucleosis luetic lymphadenitis mycobacteria-atypical / other than TB or leprosy toxoplasmosis other infections
Lymph nodes-inflammatory / reactive disorders:acute nonspecific lymphadenitis Castleman disease dermatopathic lymphadenopathy drug hypersensitivity IgG4 related lymphadenopathy indolent T lymphoblastic proliferations Kawasaki disease Kikuchi disease Kimura disease progressive transformation of germinal centers rheumatoid arthritis reactive B cell rich lymphoid proliferations that can mimic lymphoma Rosai-Dorfman disease (RDD) systemic lupus erythematosus
Lymph node-nonspecific findings:adult onset Still disease chronic lymphadenitis follicular hyperplasia granulomatous inflammation hemophagocytic lymphohistiocytosis reactive lymphadenopathy other nonspecific findings
Lymph nodes-vascular lesions:angiolipomatous hamartoma angiomyolipoma angiomyomatous hamartoma hemangioma-lymph nodes lymphangioma lymphangiomyomatosis vascular transformation of sinuses
Lymph node & spleen-nonlymphoid neoplasms:ALK+ histiocytosis amyloid EBV positive inflammatory follicular dendritic cell / fibroblastic reticular cell tumor Erdheim-Chester disease fibroblastic reticulum cell sarcoma follicular dendritic cell sarcoma (FDCS) histiocytic sarcoma indeterminate cell histiocytosis / indeterminate dendritic cell tumor interdigitating dendritic cell / reticulum cell sarcoma intranodal palisaded myofibroblastoma Langerhans cell histiocytic neoplasms metastases myofibroblastoma plasmacytoma
Spleen-general:anatomy, histology & grossing-spleen common nonspecific abnormal features splenectomy, rupture & splenosis
Spleen-congenital anomalies:accessory splenic malformations
Spleen-cysts:epithelial cyst
Spleen-infectious / inflammatory disorders:abscess acute splenitis granulomatous inflammation uncommon infections infectious mononucleosis Splendore-Hoeppli phenomenon
Spleen-other nonneoplastic disorders:amyloidosis congestive splenomegaly Gaucher disease hemophagocytic lymphohistiocytosis hereditary spherocytosis immune thrombocytopenia (ITP)
Spleen-vascular tumors:hamartoma hemangioma-spleen littoral cell angioma sclerosing angiomatoid nodular transformation
Spleen-other tumors:metastases
Topics hosted in other chapters: blastic plasmacytoid dendritic cell neoplasm (BPDCN) hairy cell leukemia hairy cell leukemia variant hepatosplenic T cell lymphoma Kaposi sarcoma myeloid sarcoma sarcoidosis Sjogren syndrome splenic marginal zone lymphoma splenic diffuse red pulp small B cell lymphoma

Lymph nodes & spleen, nonlymphoid stains: AFB CD1a CD34 CD45 CD68 CMV EBER EMA GMS HHV8 IgG4 kappa & lambda light chains Ki67 S100 Warthin-Starry

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:abscess accessory acute nonspecific lymphadenitis acute splenitis adipose tissue adult onset Still disease ALK+ histiocytosis amyloid amyloidosis anatomy & histology-lymph nodes anatomy, histology & grossing-spleen angiolipomatous hamartoma angiomyolipoma angiomyomatous hamartoma anthracosis B & T cells Castleman disease cat scratch disease chronic lymphadenitis common nonspecific abnormal features congestive splenomegaly decidual reaction dermatopathic lymphadenopathy drug hypersensitivity EBV positive inflammatory follicular dendritic cell / fibroblastic reticular cell tumor epithelial cyst epithelial inclusions Erdheim-Chester disease
F-N:fibroblastic reticulum cell sarcoma follicular dendritic cell sarcoma (FDCS) follicular hyperplasia Gaucher disease granulomatous inflammation grossing & features to report-lymph nodes hamartoma hemangioma-lymph nodes hemangioma-spleen hemophagocytic lymphohistiocytosis hereditary spherocytosis histiocytic sarcoma HIV IgG4 related lymphadenopathy immune thrombocytopenia (ITP) indeterminate cell histiocytosis / indeterminate dendritic cell tumor indolent T lymphoblastic proliferations infectious mononucleosis interdigitating dendritic cell / reticulum cell sarcoma intranodal palisaded myofibroblastoma Kawasaki disease Kikuchi disease Kimura disease Langerhans cell histiocytic neoplasms lipofuscin littoral cell angioma luetic lymphadenitis lymphangioma lymphangiomyomatosis mesothelial inclusions metastases mycobacteria-atypical / other than TB or leprosy myofibroblastoma
O-Z:other ectopic tissue / inclusions other infections other nonspecific findings other pigment / foreign material plasmacytoma progressive transformation of germinal centers reactive B cell rich lymphoid proliferations that can mimic lymphoma reactive lymphadenopathy rheumatoid arthritis Rosai-Dorfman disease (RDD) sclerosing angiomatoid nodular transformation silicone Splendore-Hoeppli phenomenon splenectomy, rupture & splenosis splenic malformations systemic lupus erythematosus toxoplasmosis uncommon infections vascular transformation of sinuses WHO system for reporting lymph node cytopathology (pending)
Lymph nodes & spleen, nonlymphoma books

Ashton-Key: 2016

Auerbach: 2022

Crane: 2021

Duffield: 2020

Hsi: 2017

Hudnall: 2019

Jaffe: 2016

Jiang: 2023

King: 2023

Medeiros: 2017

Medeiros: 2021

Medeiros: 2023

Naeim: 2018

Wang: 2020



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