Superpage - Images
Cervix

Authors: Apeksha N. Agarwal, M.B.B.S., M.D., Maryam Aghighi, M.D., Hiba Al Dallal, M.B.Ch.B., Khaled J. Alkhateeb, M.B.B.S., Léonie Alran, B.S., Jaya Ruth Asirvatham, M.D., Ryan W. Askeland, M.D., Erika M. Baardsen, D.O., Julieta E. Barroeta, M.D., Sarah M. Bean, M.D., Natalia Buza, M.D., David B. Chapel, M.D., Yevgen Chornenkyy, M.D., M.Sc., Bonnie Choy, M.D., Sabrina Croce, M.D., Ph.D., Teresa M. Darragh, M.D., Kyle Devins, M.D., Nikolina Dioufa, M.D., Sarah Farran, M.D., M.P.H., Cinzia Giacometti, M.D., Farnaz Hasteh, M.D., Lynn Hoang, M.D., Anjelica Hodgson, M.D., Ali Ismail, M.B.B.S., Lucy Jager, M.D., Soumya Jaladi, M.B.B.S., Rachel Jug, M.B.B.Ch., B.A.O., Katerina Kearns, M.D., Andreas Kontosis, M.D., Adam Lechner, B.M., Zaibo Li, M.D., Ph.D., Leonel Maldonado, M.D., Brandon Douglas Metcalf, M.D., Nada Mohamed, M.D., Carlos Parra-Herran, M.D., Nat Pernick, M.D., Branko Perunovic, D.M., John K.S.S. Philip, M.D., Jennifer Pors, M.D., Peace A. Preston, B.A., Shuyue Ren, M.D., Ph.D., Joseph Reznicek, M.D., Marilin Rosa, M.D., Agnieszka Rychlik, M.D., Ziyan T. Salih, M.D., Lauren Schwartz, M.D., Stephanie L. Skala, M.D., Sucheta Srivastava, M.D., Ashwyna Sunassee, M.D., Gulisa Turashvili, M.D., Ph.D., Philip T. Valente, M.D., Jaclyn Watkins, M.D., M.S., Katharina Wiedemeyer, M.D., Mikami Yoshiki, M.D., Ph.D.
Editorial Board Members: David B. Chapel, M.D., Bonnie Choy, M.D., Kyle Devins, M.D., Ricardo R. Lastra, M.D., Lucy Ma, M.D., Carlos Parra-Herran, M.D., Marc Pusztaszeri, M.D., Gulisa Turashvili, M.D., Ph.D.
Deputy Editors-in-Chief: Jennifer A. Bennett, M.D., Gulisa Turashvili, M.D., Ph.D.
Editor-in-Chief: Debra L. Zynger, M.D.

Copyright: 2002-2024, PathologyOutlines.com, Inc.

Gyn related: Jobs, Fellowships, Conferences, Cases, CME, Board Review, What's New

Related chapters: Uterus, Vulva, vagina & female urethra

Editorial Board oversight: David B. Chapel, M.D. (last reviewed December 2023)

Actinomycosis
Cytology images

Contributed by Marilin Rosa, M.D.

Actinomyces



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Actinomyces

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IUD related changes


Adenocarcinoma in situ
Clinical images

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Colposcopy

Microscopic (histologic) images

Contributed by Gulisa Turashvili, M.D., Ph.D., Seema Khutti, M.D., Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.
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AIS admixed with HSIL

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AIS, gastric type

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p16 in SMILE

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Mucicarmine in SMILE


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SMILE

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Glands with crowding and stratification

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Abundant mitosis and apoptosis

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AIS with adjacent uninvolved glands


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Transition to AIS

AIS p16

High grade cervical
glandular intraepithelial
neoplasia

High power

Nuclear atypia

Cytology images

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Atypical glandular cells
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Groups of atypical rosette-like structures

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Feathering

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Feathering and enlarged hyperchromatic nuclei

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Palisading and enlarged nuclei


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Palisading and feathering

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Forming a rosette-like structure

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Enlarged nuclei

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Feathering and enlarged nuclei


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Homogenous chromatin pattern

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Slightly atypical metaplastic cells


Adenoid basal carcinoma
Microscopic (histologic) images

Contributed by Stephanie L. Skala, M.D.
Central squamous differentiation Central squamous differentiation

Central squamous differentiation

Peripheral palisading

Peripheral palisading

Cytoplasmic clearing

Cytoplasmic clearing

p16 block positivity p16 block positivity

p16 block positivity

Cytology images

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Clusters of bland cells with peripheral palisading


Adenoid cystic carcinoma
Gross images

Contributed by Ihab Hosny, M.D.
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Various images

Microscopic (histologic) images

AFIP images

Cribriform architecture and basement membrane material


Contributed by Carlos Parra-Herran, M.D.


Contributed by Ihab Hosny, M.D.

Vascular invasion

Actin

CEA


EMA

High molecular weight keratin

S100

Cytology images

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Three dimensional structures


Adenomyoma
Radiology images

Contributed by Leonel Maldonado, M.D.
MRI of the pelvis

MRI of the pelvis

Sagittal T2

Sagittal T2

Microscopic (histologic) images

Contributed by Cinzia Giacometti, M.D.
Benign endocervical glands

Benign endocervical glands

Glands with bland cytology

Glands with bland cytology

Admixture with smooth muscle

Admixture with smooth muscle

Glands of different sizes

Glands of different sizes

Tubal differentiation

Tubal differentiation


αSMA

αSMA

Desmin

Desmin

ER

ER

PR

PR

PAX8

PAX8


Adenosarcoma
Gross images

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Endocervical polypoid lesion

Microscopic (histologic) images

Contributed by Carlos Parra-Herran, M.D. and AFIP images
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High grade adenosarcoma

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Adenosarcoma with sarcomatous overgrowth

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Low grade adenosarcoma

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Phyllodes tumor-like pattern




Contributed by Ayse Ayhan, M.D., Ph.D.
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Biphasic tumor

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Periglandular cuff


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Intraglandular papillae

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Stromal mitoses

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Squamous metaplasia


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Sarcomatous overgrowth

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Heterologous elements


Adenosquamous carcinoma
Gross images

AFIP images

Bulky exophytic mass

Microscopic (histologic) images

AFIP images

Poorly formed glands and squamous components

Sheets of cells with abundant lightly stained cytoplasm

Distinct cell border and prominent nucleoli

Cytology images

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Abundant granular cytoplasm


Alveolar soft part sarcoma
Radiology images

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Lobulated, hypervascular mass originating in the cervix

Lobulated, hypervascular mass originating in the cervix

Well defined mass extending from cervix into vagina

Well defined mass extending from cervix into vagina

Gross images

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Well circumscribed, lobulated mass

Well circumscribed, lobulated mass

Microscopic (histologic) images

Contributed by Katharina Wiedemeyer, M.D. and W. Glenn McCluggage, M.D.
Nested pattern

Nested pattern

Solid pattern

Solid pattern

Vasculature

Vasculature

ASPS consists of polygonal cells

Polygonal cells

ASPS, cells with granular cytoplasm

Cells with granular cytoplasm


ASPS, cells with monomorphic nuclei and moderate atypia

Cells with monomorphic nuclei and moderate atypia

TFE3

TFE3

Cathepsin K

Cathepsin K

SMA

SMA

Electron microscopy images

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Cytoplasmic electron dense secretory granules / rod shaped crystals

Cytoplasmic electron
dense secretory
granules / rod shaped
crystals

Molecular / cytogenetics images

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FISH test detecting ASPL::TFE3 fusion gene in tumor cells

ASPL::TFE3 fusion gene in tumor cells


Anatomy
Diagrams / tables

Contributed by Nada Mohamed, M.D.
Schematic of cervical anatomy

Schematic of cervical anatomy



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Migration of squamocolumnar junction with age

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Local anatomy

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Microanatomy


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Sagittal section of local anatomy

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Uterus, cervix and vagina

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Vasculature

Radiology images

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Zonal anatomy of cervix

Clinical images

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Normal cervix colposcopy

Migration of squamocolumnar junction with age

Gross images

Contributed by Misty Hensch, P.A.
Anatomy of cervix

Anatomy of cervix



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Nulliparous cervix

Microscopic (histologic) images

Contributed by Nada Mohamed, M.D.
Normal cervical squamous epithelium

Normal cervical squamous epithelium

Normal cervical glandular epithelium

Normal cervical glandular epithelium

Videos

Histology of the cervix


Arias Stella reaction
Microscopic (histologic) images

Contributed by Leonel Maldonado, M.D.

Arias-Stella reaction, 10×

Arias-Stella reaction, 20×


ASC-H (cytology)
Diagrams / tables

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Management algorithm for patients

Cytology images

Contributed by Bonnie Choy, M.D.

High N:C ratio

Irregular nuclear membranes and hyperchromasia

HSIL

Squamous metaplasia

Atrophy with inflammation

Endometrial cells



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WHO digital atlas


ASCUS (cytology)
Diagrams / tables

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Management algorithm for patients < 25 years

Cytology images

Contributed by Joseph Reznicek, M.D., Bonnie Choy, M.D. and Lucy Jager, M.D.
Enlarged nuclei Enlarged nuclei

Enlarged nuclei

Slight hyperchromasia

Slight hyperchromasia

Atypical parakeratosis

Atypical parakeratosis

Radiation changes

Radiation changes


LSIL

LSIL

Pseudokoilocytes Pseudokoilocytes

Pseudokoilocytes

Herpes cytopathic effect

Herpes cytopathic effect



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WHO digital atlas


Atrophy
Cytology images

Contributed by Marilin Rosa, M.D.

Atrophic sheet



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Various images

Videos


Atypical glandular cells (cytology)
Diagrams / tables

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Algorithm for initial workup of AGC

Algorithm for initial workup of AGC

Algorithm for management after diagnostic examination

Algorithm for management after diagnostic examination

Cytology images

Contributed by Joseph Reznicek, M.D.
Atypical endocervical cells, favor neoplastic Atypical endocervical cells, favor neoplastic Atypical endocervical cells, favor neoplastic

Atypical endocervical cells, favor neoplastic

Atypical glandular cells, NOS

Atypical glandular cells, NOS


Atypical glandular cells, NOS Atypical glandular cells, NOS

Atypical glandular cells, NOS

Endocervical adenocarcinoma

Endocervical adenocarcinoma

Endometrial adenocarcinoma

Endometrial adenocarcinoma



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WHO digital atlas


Bacterial vaginosis
Cytology images

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Conventional smears


Bethesda system
Cytology images

Contributed by Rachel Jug, M.B.B.Ch., B.A.O. and Sarah M. Bean, M.D.
Resembling koilocytes

Resembling koilocytes

Nuclear enlargement

Nuclear enlargement

Koilocyte

Koilocyte

Binucleation

Binucleation

High nuclear to cytoplasmic ratio

High N:C ratio


Hyperchromasia

Hyperchromasia

Nuclear contour irregularities

Nuclear contour irregularities

Binucleated cell with hyperchromasia, LSIL

Binucleated cell with hyperchromasia, LSIL

Hyperchromatic nucleus and small halo, ASCUS

Hyperchromatic nucleus and small halo, ASCUS

Nuclear overlap and elongation, atypical glandular cells

Nuclear overlap and elongation, atypical glandular cells


Hyperchromatic and irregular nucleus, atypical glandular cells

Hyperchromatic and irregular nucleus, atypical glandular cells


Blue nevus
Microscopic (histologic) images

AFIP images

Pigment containing nevus cells in cervical stroma


Candida / fungi
Cytology images

Contributed by @AnaPath10 on Twitter
Candida / fungi

Candida / fungi

Candida / fungi

Candida / fungi

Candida / fungi

Candida / fungi



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Candida albicans

Candida albicans


Chlamydia trachomatis
Cytology images

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Various images


Chronic cervicitis
Microscopic (histologic) images

Contributed by Ali Ismail, M.B.B.S.

Chronic inflammation

Cytology images

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Lymphofollicular cervicitis in a
53 year old woman


Clear cell carcinoma
Clinical images

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Vascularized, indurated lesion

Vascularized, indurated lesion

Gross images

Contributed by Philip T. Valente, M.D.
Tan-white lesion

Tan-white lesion



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Exophytic mass on the posterior lip of cervix

Exophytic mass on the posterior lip of cervix

Didelphys uterus with a cervical mass

Didelphys uterus with a cervical mass

Microscopic (histologic) images

Contributed by Nadia Hameed, M.D.
Tubulocystic pattern Tubulocystic pattern

Tubulocystic pattern

Tubulocystic pattern

Tubulocystic pattern

Papillary pattern Papillary pattern

Papillary pattern


Papillary pattern

Papillary pattern

Solid pattern Solid pattern

Solid pattern

Solid pattern

Solid pattern

Rare intracytoplasmic eosinophilic globules

Rare intracytoplasmic eosinophilic globules

Cytology images

Contributed by Nadia Hameed, M.D.
SurePath Pap test SurePath Pap test

SurePath Pap test

Electron microscopy images

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Mitochondria and rough endoplasmic reticulum

Mitochondria and rough endoplasmic reticulum

Videos

Clear cell neoplasms of the gynecologic tract


CMV
Microscopic (histologic) images

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Intracytoplasmic inclusions #1 (endocervical cells)

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#2 (endothelial cells)

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CMV+ glands and stroma

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Associated acute inflammatory infiltrate

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Intracytoplasmic vacuoles within endocervical glandular cells

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Fibrin thrombi within small vessels



Not cervix:
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Lung #1 - Giemsa stain

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Kidney

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Pancreas


Decidual reaction
Microscopic (histologic) images

Contributed by Aung Phyo, M.D. (Case #480)
Decidualized cervical nodule

Decidualized cervical nodule

Multiple prominent nucleoli

Multiple prominent nucleoli

Low N:C ratio

Low N:C ratio

Intermixed lymphocytes

Intermixed lymphocytes


Embryology
Diagrams / tables

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Female genital tract development

Müllerian duct embryonic formation

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Fusion of Müllerian ducts

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Classic theory versus Acien theory

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Congenital uterine malformations

Radiology images

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MRI showing uterovaginal absence

Hysterosalpingogram
showing double
cervix

Clinical images

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Speculum examination showing double cervix

Gross images

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Fetal female reproductive tract

Microscopic (histologic) images

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Fusion of Müllerian ducts to UVC

Histology of UVC

Cervical development

Videos

Female genital tract embryology


Endocervical polyp
Clinical images

Images hosted on other servers:
Colposcopy

Colposcopy

Polyp

Gross images

Contributed by Natalia Buza, M.D.
Small polyp

Small polyp

Microscopic (histologic) images

Contributed by Natalia Buza, M.D. and Andrey Bychkov, M.D., Ph.D.
Thick walled arteries

Thick walled arteries

Microglandular hyperplasia

Microglandular hyperplasia

Squamous metaplasia

Squamous metaplasia

Chronic inflammation

Chronic inflammation

Mitoses

Mitoses

Cystically dilated glands

Cystically dilated glands


Endometrial adenocarcinoma (cytology)
Cytology images

Contributed by Marilin Rosa, M.D. and Carmen Luz, M.D.
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Endometrial adenocarcinoma

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Endometrial group with atypia



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Various images


Endometriosis
Microscopic (histologic) images

AFIP images

Endometriosis


Gastric type adenocarcinoma
Radiology images

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Barrel shaped cervix on MRI in MDA

Ill defined cervical mass on MRI in MDA

Gross images

Contributed by Gulisa Turashvili, M.D., Ph.D.

Radical hysterectomy for gastric type adenocarcinoma



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Bulging cervix in MDA

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Cervical swelling without a mass in MDA

Microscopic (histologic) images

Contributed by Gulisa Turashvili, M.D., Ph.D.

Well differentiated gastric type adenocarcinoma

Poorly differentiated gastric type adenocarcinoma

Well differentiated gastric type adenocarcinoma


Gastric type adenocarcinoma in hysterectomy

Poorly differentiated gastric type adenocarcinoma

Gastric type adenocarcinoma involving fallopian tube

Cytology images

Contributed by Gulisa Turashvili, M.D., Ph.D.

Gastric type adenocarcinoma on Pap cytology


Glial polyp
Microscopic (histologic) images

AFIP images

Polypoid mass of glia below endocervical surface



Case #135

H&E and GFAP


Grossing
Gross images

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Grossing diagrams

Diagrams / tables

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Hysterectomy specimen


Histology
Diagrams / tables

Contributed by Kyle Devins, M.D.

Schematic of exocervix and transformation zone



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Location of glandular and squamous epithelium

Gross images

Contributed by Kyle Devins, M.D.

Uterus and cervix

Bivalved uterus and cervix

Microscopic (histologic) images

Contributed by Kyle Devins, M.D.

Squamocolumnar junction

Cervical squamous epithelium

Benign endocervical glands


Dilated endocervical glands

Normal cervical squamous p16 IHC

Normal endocervical p16 IHC


HPV associated adenocarcinoma (usual type and variants)
Microscopic (histologic) images

Contributed by Carlos Parra-Herran, M.D.
Adenocarcinoma in situ

Adenocarcinoma in situ

Invasive adenocarcinoma, pattern A

Invasive adenocarcinoma, pattern A

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Invasive adenocarcinoma, pattern B


Invasive adenocarcinoma, pattern C Invasive adenocarcinoma, pattern C Invasive adenocarcinoma, pattern C

Invasive adenocarcinoma, pattern C



Contributed by Tanner Storozuk, M.D. and Jennifer Bennett, M.D. (Case #495)

Invasive stratified mucin producing carcinoma (iSMILE)

Cytology images

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Inflammatory exocervical smear


HPV associated cervical squamous cell carcinoma
Radiology images

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MRI

Gross images

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Stage I

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Stage III

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Stage IV

Microscopic (histologic) images

Contributed by Gulisa Turashvili, M.D., Ph.D., Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.

Tumor involving transformation zone

Nests of epithelioid cells

Deeply infiltrative tumor

Atypical epithelioid cells

Atypical cells


Atypical cells within inflamed stroma

Marked pleomorphism

Bizarre cells

p16 immunostain

p16 immunostain

HPV in situ hybridization

HPV in situ hybridization

Cytology images

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Pleomorphic malignant cells

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Pleomorphic and keratinized malignant cells

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Pleomorphic malignant cells, isolated or in clusters

Electron microscopy images

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Tumor cell in intratumoral vessel


HSIL (cytology)
Cytology images

Contributed by Yevgen Chornenkyy, M.D., M.Sc. and Bonnie Choy, M.D.
High N/C ratio

High N/C ratio

Metaplastic or dense cytoplasm

Metaplastic or dense cytoplasm

Irregular nuclear contour, prominent indentations / grooves

Irregular nuclear contour, indentations / grooves

Lack of nucleoli

Lack of nucleoli

Variable cytoplasm

Variable cytoplasm



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WHO digital atlas


HSIL / CIN II / CIN III
Clinical images

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Low grade disease with unsatisfactory colposcopy

Acetowhite epithelium

High grade disease and unsatisfactory colposcopy

Before acetic acid

Dense acetowhite epithelium after acetic acid

Before acetic acid


Acetowhite epithelium

Microscopic (histologic) images

Contributed by Khaled J. Alkhateeb, M.B.B.S.
Squamocolumnar junction HSIL

Squamocolumnar junction HSIL

Cytoplasmic maturation

Cytoplasmic maturation

CIN III involving endocervical glands

CIN III involving endocervical glands

Full thickness atypia

Full thickness atypia

HSIL involving endocervical glands

HSIL involving endocervical glands


HSIL with superficial keratinization

HSIL with superficial keratinization

HSIL / CIN III with adjacent squamous cell carcinoma

HSIL / CIN III with adjacent squamous cell carcinoma

Invasive squamous cell carcinoma

Invasive squamous cell carcinoma

HSIL with significant nuclear pleomorphism

HSIL with significant nuclear pleomorphism

p16 IHC

p16 IHC

Cytology images

Contributed by Ziyan T. Salih, M.D.
Marked nuclear atypia

Marked nuclear atypia

Sharp contrast from surrounding benign cells

Sharp contrast from surrounding benign cells


Invasive stratified mucin producing carcinoma
Microscopic (histologic) images

Contributed by Julieta E. Barroeta, M.D., Andreas Kontosis, M.D. and Ricardo R. Lastra, M.D.
Infiltrative nests Infiltrative nests

Infiltrative nests

Intratumoral and peritumoral inflammation

Intratumoral and peritumoral inflammation

Metastatic ISMC

Metastatic ISMC

SMILE and AIS

SMILE and AIS


Mucicarmine

Mucicarmine

p16 IHC

p16 IHC

PAX8 IHC

PAX8 IHC

p40 IHC

p40 IHC

ER IHC

ER IHC


Lactobacillus
Cytology images

Contributed by Hiba Al Dallal, M.D.
Cytolysis Cytolysis

Cytolysis

Cytolysis

Cytolysis


Lactobacillus on the top of squamous cells Lactobacillus on the top of squamous cells Lactobacillus on the top of squamous cells Lactobacillus on the top of squamous cells

Lactobacillus on the top of squamous cells

Videos

Lactobacillus, normal vaginal bacterial rods


Large cell neuroendocrine carcinoma
Microscopic (histologic) images

Case #327
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H&E


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CK7

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p16

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Chromogranin

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Synaptophysin

Electron microscopy images

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Pseudorosette


Leptothrix
Cytology images

Contributed by Ziyan T. Salih, M.D.
Cytologic smear with <i>Leptothrix</i> Cytologic smear with <i>Leptothrix</i>

Cytologic smear with Leptothrix



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Filamentous Leptothrix in a cytologic preparation

Filamentous Leptothrix species

Leptothrix

Leptothrix

LBC: <i>Leptothrix</i> with <i>Trichnomonas</i>

LBC: Leptothrix with Trichomonas

Long, filamentous structure

Long, filamentous structure


Lobular endocervical glandular hyperplasia
Diagrams / tables

Images hosted on other servers:
Gastric type cervical lesion spectrum

Gastric type cervical lesion spectrum

Proposed management algorithm

Proposed management algorithm

Radiology images

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LEGH with cosmos pattern LEGH with cosmos pattern LEGH with cosmos pattern

LEGH with cosmos pattern

Microscopic (histologic) images

Contributed by Carlos Parra-Herran, M.D.
Densely packed glands

Densely packed glands

Round mucinous glands

Round mucinous glands

Lobulated / floret-like appearance

Lobulated / floret-like appearance

Glands lined by benign columnar cells

Glands lined by benign columnar cells

PAS - Alcian blue stain PAS - Alcian blue stain

PAS - Alcian blue stain



Contributed by @MirunaPopescu13 on Twitter
Lobular endocervical glandular hyperplasia

Lobular endocervical glandular hyperplasia

Cytology images

Images hosted on other servers:
LEGH and MDA

LEGH and MDA


LSIL (cytology)
Cytology images

Contributed by Lucy Jager, M.D. and Bonnie Choy, M.D.

Nuclear enlargement and hyperchromasia

Multinucleation

Binucleation and perinuclear cavitation

Koilocytosis with nuclear abnormalities


Koilocytosis with nuclear abnormalities

Pseudokoilocytes

Herpes cytopathic effect



Images hosted on other servers:
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WHO digital atlas


LSIL / CIN I
Clinical images

Images hosted on other servers:
Colposcopy - acetowhite lesion

Colposcopy - acetowhite lesion

Microscopic (histologic) images

Contributed by Ziyan T. Salih, M.D.
LSIL / koilocytic atypia

LSIL / koilocytic atypia

Koilocytic atypia

Koilocytic atypia

Cervical biopsy (LSIL) Cervical biopsy (LSIL)

Cervical biopsy (LSIL)

Cytology images

Contributed by Ziyan T. Salih, M.D.
Koilocytosis (LSIL) Koilocytosis (LSIL)

Koilocytosis (LSIL)

Videos

Squamous lesions of the cervix and their differential diagnosis
by Carlos Parra-Herran, M.D.


Lymphoepithelioma-like carcinoma
Microscopic (histologic) images

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Vagina: well circumscribed tumor


Lymphoma
Cytology images

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Various Images


Müllerian papilloma
Microscopic (histologic) images

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Various images and immunostains

Papillary tumor with various epithelial types

Focal atypia due
to stratification,
pleomorphism and
atypical mitotic figure


Mesonephric adenocarcinoma
Radiology images

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MRI cervical tumor

Microscopic (histologic) images

Contributed by Lynn Hoang, M.D.

Mix of morphologic patterns

Tubular pattern

Tubular pattern with adjacent mesonephric remnants

Tubular pattern with desmoplasia

Ductal
(pseudoendometrioid)
pattern

Ductal pattern


Papillary pattern

Sieve-like pattern

Solid pattern

Mesonephric carcinosarcoma


GATA3+

ER-

TTF1+

CD10+

Wild type p53


Mesonephric rests and mesonephric hyperplasia
Microscopic (histologic) images

Contributed by Katerina Kearns, M.D., Michela Campora, M.D., Carlos Parra-Herran, M.D. and Nikolina Dioufa, M.D.
Bland glands deep in cervical stroma Bland glands deep in cervical stroma

Bland glands deep in cervical stroma

Glandular epithelium Glandular epithelium

Glandular epithelium

Glandular epithelium

Glandular epithelium

Luminal secretions

Luminal secretions


Small gland and tubule-like structures

Small gland and tubule-like structures

Vague lobular configuration

Vague lobular configuration

Glandular spaces

Glandular spaces

Eosinophilic material

Eosinophilic material

Clusters of tubules

Clusters of tubules

PAS

PAS


GATA3

GATA3

mCEA

mCEA

p16

p16

PAX2

PAX2

PAX8

PAX8


Metastases
Microscopic (histologic) images

AFIP images

Breast carcinoma metastatic to cervix



Case #125 (metastatic lobular carcinoma to endometrial polyp)

Various images


ER

PR

GCDFP-15

Cytology images

Contributed by Carmen Luz, M.D.
Missing Image

Ovarian clear cell carcinoma


Microglandular hyperplasia
Microscopic (histologic) images

Contributed by Gulisa Turashvili, M.D., Ph.D.
Benign glandular proliferation

Benign glandular proliferation

Back to back glands lacking atypia

Back to back glands lacking atypia

Bland epithelial lining

Bland epithelial lining

Rare mitosis

Rare mitosis

Cytology images

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Isolated rounded endocervical cells


Nabothian cysts
Radiology images

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Nabothian cysts on computed tomography

Clinical images

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Multiple nabothian cysts

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Nabothian cyst

Gross images

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Nabothian cysts

Microscopic (histologic) images

Contributed by Gulisa Turashvili, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.

Cystically dilated glands

Bland epithelial lining

Endocervical polyp with nabothian cysts

Endocervical polyp with nabothian cysts


Neuroendocrine tumor (carcinoid and atypical carcinoid)
Gross images

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Hysterectomy specimen


Normal and nonneoplastic findings
Cytology images

Contributed by Shuyue Ren, M.D., Ph.D.

Squamous cells, superficial

Squamous cells, intermediate

Squamous cells, parabasal and basal cells

Endocervical glandular cells

Endometrial cells

Endometrial cells: exodus


Squamous cells: bland enlargement

Hyperkeratosis

Parakeratosis

Tubal metaplasia

Squamous metaplasia

Neutrophils


Abundant blood

Glandular cells status posthysterectomy

Reactive changes
associated with
inflammation


Postoperative spindle cell nodule
Microscopic (histologic) images

Contributed by Aarti Sharma, M.D.
Whorled architecture

Whorled architecture

Myxoid stroma

Myxoid stroma

Chronic inflammation Chronic inflammation

Chronic inflammation

Mitotic activity

Mitotic activity

Bland cytomorphology

Bland cytomorphology


Primary endometrioid adenocarcinoma (HPV independent)
Microscopic (histologic) images

Contributed by David B. Chapel, M.D.
Cervical endometriosis Cervical endometriosis

Cervical endometriosis

Cervical endometrioid adenocarcinoma, FIGO grade 1 Cervical endometrioid adenocarcinoma, FIGO grade 1 Cervical endometrioid adenocarcinoma, FIGO grade 1

Cervical endometrioid adenocarcinoma, FIGO grade 1

Minimal deviation endometrioid adenocarcinoma

Minimal deviation endometrioid adenocarcinoma

Videos

HPV independent glandular lesions

Benign endocervical lesions

Cytology: glandular cervical lesions


Pseudolymphoma
Microscopic (histologic) images

AFIP images

Dense lymphoid
infiltrate with
germinal centers


Radiation atypia
Microscopic (histologic) images

Contributed by Carlos Parra-Herran, M.D.

Radiation atypia - squamous epithelium

Radiation atypia - vascular endothelium

Cytology images

Contributed by Erika Baardsen, D.O.

Pap smear



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Pap smear


Rhabdomyosarcoma
Radiology images

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Vaginal embryonal rhabdomyosarcoma

Clinical images

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Cervical embryonal
rhabdomyosarcoma

Gross images

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Gray surface and areas of hemorrhage

Microscopic (histologic) images

Contributed by Kyle Devins, M.D.
Edematous stroma

Edematous stroma

Cambium layer

Cambium layer

Rhabdomyoblasts

Rhabdomyoblasts

Hyaline cartilage

Hyaline cartilage

Nests, sheets and alveolar spaces

Nests, sheets and alveolar spaces


Alveolar spaces

Alveolar spaces

Desmin

Desmin

Myogenin

Myogenin

Nuclear pleomorphism

Nuclear pleomorphism

Cytology images

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Brushing of
uterine embryonal
rhabdomyosarcoma


Small cell neuroendocrine carcinoma
Microscopic (histologic) images

AFIP and Case #327

Sheets of small cells with scant cytoplasm and hyperchromatic nuclei

H&E


CK7

p16

Chromogranin

Synaptophysin

Cytology images

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Lesional cells, Pap

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Single necrotic cells, Pap

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Amphophilic cytoplasm

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Large aggregates of malignant cells


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Malignant cells loosely cohesive

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Scant cytoplasm

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PanCK

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Synaptophysin

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p16


SMILE (stratified mucin producing intraepithelial lesions)
Microscopic (histologic) images

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Resembles HSIL but with abundant mucin

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Adenocarcinoma in situ stratified type


Squamous metaplasia
Clinical images

Contributed by Masatsugu Ueda, M.D.
Transformation zone Transformation zone

Transformation zone

Gross images

Contributed by Mikami Yoshiki, M.D., Ph.D.
Transformation zone Transformation zone

Transformation zone

Microscopic (histologic) images

Contributed by Mikami Yoshiki, M.D., Ph.D.
Transformation zone

Transformation zone

Primary squamocolumnar junction

Primary squamocolumnar junction

Secondary squamocolumnar junction

Secondary squamocolumnar junction

Squamous metaplasia overlying preexisting glands.

Squamous metaplasia
overlying
preexisting glands

Reserve cell hyperplasia Reserve cell hyperplasia

Reserve cell hyperplasia


Immature squamous metaplasia Immature squamous metaplasia

Immature squamous metaplasia

Squamous metaplasia involving endocervical glands Squamous metaplasia involving endocervical glands

Squamous metaplasia involving endocervical glands

Cytology images

Contributed by Mikami Yoshiki, M.D., Ph.D.
Squamous metaplasia

Squamous metaplasia


Trichomonas vaginalis
Diagrams / tables

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Trophozoite

Clinical images

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Strawberry cervix

Cytology images

Contributed by Soumya Jaladi, M.B.B.S., Marilin Rosa, M.D., @zaalruwai83 and @DrVasudevPrabhu on Twitter

Trichomonas in a cytologic preparation

Trichomonas

Trichomonas vaginalis

Trichomonas vaginalis


Trichomonas vaginalis Trichomonas vaginalis

Trichomonas vaginalis

Trichomonas vaginalis Trichomonas vaginalis

Trichomonas vaginalis



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Filamentous Leptothrix species

Trichomonas in wet mount

Trichomonas in conventional
Pap smear

Trichomonas vaginalis with Leptothrix

Trichomonas


Trophozite

Inflammatory ectocervix with Trichomonas infection

Electron microscopy images

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T. vaginalis parasite


Tuboendometrioid metaplasia
Microscopic (histologic) images

Contributed by Carlos Parra-Herran, M.D.

TEM and relevant stains


Tunnel clusters
Microscopic (histologic) images

Contributed by Gulisa Turashvili, M.D., Ph.D.

Type A tunnel clusters

Alcian blue / PAS in type A tunnel clusters


Type B tunnel clusters

Alcian blue / PAS in type B tunnel clusters


Vasculitis
Microscopic (histologic) images

Case #91
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Inflammatory infiltrate in the vessel wall

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Lymphocytes, neutrophils and occasional eosinophils

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Fibrinoid necrosis within the media

Back to top
Recent Cervix Pathology books

Ali: 2019

Clement: 2019

Crum: 2017

Howitt: 2019

Hui: 2015

IARC: 2020

Malpica: 2015

Mody: 2022

Nayar: 2015

Nucci: 2020

Nucci: 2023

Nucci: 2023

Soslow: 2020

Vang: 2023

Zheng: 2019

Zheng: 2019



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