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Breast-nonmalignant
Inflammatory / infectious
Sarcoidosis
Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)
Revised: 10 April 2010, last major update April 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Idiopathic systemic granulomatous disorder of noncaseating, epithelioid granulomas with multinucleated giant cells
● Usually involves lungs with fibrosis; also lymph nodes, skin, liver, spleen, phalanges, bones, parotid gland
● Rare in breast; either begins in breast or part of known disease
Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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● Abnormal breast examinations or mammograms present in 2% of sarcoidosis patients, granulomas in 1% (Sarcoidosis Vasc Diffuse Lung Dis 2001;18:301)
● Occasionally begins in breast and remains localized for long periods
● May mimic metastatic breast cancer (Clin Breast Cancer 2007;7:804)
Prognostic factors
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Case reports
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● 41 year old woman with diffusely involved breast (Br J Radiol 2008;81:e231)
● 51 year old woman with systemic disease and breast mass (Eur Rev Med Pharmacol Sci 2006;10:47, free full text)
Treatment
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Clinical images
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Gross description (Macroscopy)
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Gross images
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Micro description (Histopathology)
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● Noncaseating, epithelioid granulomas with multinucleated giant cells
● No/rare necrosis
Micro images
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Stromal granulomas DCIS (arrow) with Infiltrating lobular carcinoma
sparing lobules sarcoid-like granuloma and sarcoid-like granuloma
Non-necrotizing granulomatous inflammation
Lymph node
Drawings
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Virtual Slides
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Videos
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Cytology description
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● Epithelioid cells and lymphocytes
Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Mycobacteria, fungi, foreign material, granulomatous mastitis
Additional references
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● Arch Pathol Lab Med 1984;108:673, Hum Pathol 1985;16:851, Hum Pathol 1985;16:185, Wikipedia
End of Breast-nonmalignant > Inflammatory / infectious > Sarcoidosis
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