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Breast-nonmalignant

Inflammatory / infectious

Sarcoidosis

 

Reviewer: Hind Nassar, M.D. in January 2009 (see Authors page)

Revised: 30 September 2012, last major update April 2010

Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

 

Definition

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● Idiopathic systemic granulomatous disorder of noncaseating, epithelioid granulomas with multinucleated giant cells

● Usually involves lungs with fibrosis; also lymph nodes, skin, liver, spleen, phalanges, bones, parotid gland

● Rare in breast; either begins in breast or part of known disease

 

Terminology

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Epidemiology

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Sites

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Etiology

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Clinical features

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● Abnormal breast examinations or mammograms present in 2% of sarcoidosis patients, granulomas in 1% (Sarcoidosis Vasc Diffuse Lung Dis 2001;18:301)

● Occasionally begins in breast and remains localized for long periods

● May mimic metastatic breast cancer (Clin Breast Cancer 2007;7:804)

 

Prognostic factors

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Case reports

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● 41 year old woman with diffusely involved breast (Br J Radiol 2008;81:e231)

● 51 year old woman with systemic disease and breast mass (Eur Rev Med Pharmacol Sci 2006;10:47, free full text)

 

Treatment

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Clinical images

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Gross description (Macroscopy)

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Gross images

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Micro description (Histopathology)

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● Noncaseating, epithelioid granulomas with multinucleated giant cells

● No/rare necrosis

 

Micro images

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Stromal granulomas         DCIS (arrow) with                               Infiltrating lobular carcinoma

sparing lobules                   sarcoid-like granuloma                    and sarcoid-like granuloma

 

 

         

Non-necrotizing granulomatous inflammation

 

 

       

Lymph node

 

Drawings

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Virtual Slides

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Videos

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Cytology description

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● Epithelioid cells and lymphocytes

 

Cytology images

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Positive stains

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Negative stains

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Electron microscopy descriptions

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Electron microscopy images

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Molecular / cytogenetics description

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Molecular / cytogenetics images

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Differential Diagnosis

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● Mycobacteria, fungi, foreign material, granulomatous mastitis

 

Additional references

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Arch Pathol Lab Med 1984;108:673Hum Pathol 1985;16:851Hum Pathol 1985;16:185, Wikipedia

 

End of Breast-nonmalignant > Inflammatory / infectious > Sarcoidosis

 

 

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