Stomach
Polyps
Cronkhite-Canada
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 1 September 2020
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: Cronkhite-Canada syndrome
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Differential diagnosisCite this page: Weisenberg E. Cronkhite-Canada. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachcronkhite.html. Accessed January 10th, 2025.
Definition / general
- Very rare juvenile polyposis disorder with diffuse GI polyposis, alopecia, hyperpigmentation, dystrophic changes in fingernails and toenails
- Nonhereditary, unknown etiology
- Onset usually in middle age adults
- Patients may have diarrhea, weight loss, abdominal pain, anorexia, weakness, hematochezia
- Occasionally gastric adenocarcinoma, adenocarcinoma anywhere in GI tract (Am J Surg Pathol 1985;9:65)
Case reports
- With alopecia and CMV infection (Arch Pathol Lab Med 1977;101:432)
Microscopic (histologic) description
- Polyp with broad sessile base, expanded edematous lamina propria, cystic glands (Am J Surg Pathol 1989;13:940)
Differential diagnosis
- Juvenile polyps
- Ménétrier's disease: need endoscopic findings and clinical history
