Stomach
Gastritis
IBD-related gastritis
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 28 December 2020
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: Crohn's disease gastritis
Table of Contents
Crohn's disease | Ulcerative colitis | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Weisenberg E. IBD-related gastritis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachcrohn.html. Accessed January 10th, 2025.
Crohn's disease
- Clinical involvement rare, microscopic disease is more common
- Gastric granulomas in 9-15%
- High proportion of Crohn's patients show upper GI involvement,usually antral (Virchows Arch 1998;432:49)
- Focal acute inflammation in a background of non-inflamed, H. pylori negative mucosa is suggestive of Crohn's disease (Am J Surg Pathol 1998;22:383, Gut 1996;38:379)
- Active inflammation in 56% (some inflammatory changes in up to 70%), but only 10% are H. pylori positive
Ulcerative colitis
- Gastric involvement is rare, may occur with duodenal involvement (J Clin Gastroenterol 2004;38:46, Am J Surg Pathol 2000;24:1407)
- More common in children
- Described after total colectomy (J Clin Gastroenterol 2013;47:52)
Microscopic (histologic) description
- Most common upper GI inflammatory pattern is focal gastritis, followed by gastric basal mixed inflammation and superficial plasmacytosis (Am J Surg Pathol 2010;34:1672)
- Variable changes in ulcerative colitis include multiple tiny shallow ulcers, crypt abscess formation, increased intraepithelial lymphocytes, villous blunting; microscopic findings parallel remissions and relapses of colonic inflammation
Microscopic (histologic) images
Images hosted on other servers:
Focal lesion in
atral mucosa
resembling active
Crohn's disease
Differential diagnosis
- Granulomas of Crohn's disease:
- Foreign-body
- Fungus
- Granulomatous gastritis
- Sarcoid
- Tuberculosis
- Tumor
- Whipple’s disease
