Stomach
Polyps
Cowden
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 28 December 2020
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: Cowden syndrome
Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Weisenberg E. Cowden. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachcowdens.html. Accessed January 10th, 2025.
Definition / general
- Also known as multiple hamartoma syndrome
- Due to rare autosomal dominant germline mutation in PTEN on 10q23
- Tricholemmomas on face, acral keratoses, oral papillomas, GI polyps that may occur in stomach, small intestine or colon (35 - 40%), increased incidence of breast and thyroid carcinomas, also endometrial and renal cell carcinomas
Gross description
- Small (1 - 2 mm), sessile polyps
Microscopic (histologic) description
- Excess lamina propria splayed and dissected into lobules by disorganized fascicles of muscularis mucosa running upward from base of mucosa
Microscopic (histologic) images
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Gastric and colonic polyps
