Stomach
Hypertrophic gastropathy
Zollinger-Ellison
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 1 September 2020
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: Zollinger-Ellison syndrome
Cite this page: Weisenberg E. Zollinger-Ellison. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachZE.html. Accessed January 21st, 2025.
Definition / general
- Duodenal ulceration, diarrhea and gastric gland hyperplasia caused by serum hypergastrinemia from pancreatic or duodenal neoplasm, or rarely by primary G cell hyperplasia of antral mucosa
- Grossly and radiologically resembles Menetrier's disease
- Associated with MEN1 syndrome and multicentric carcinoid tumors (Am J Surg Pathol 1990;14:503)
- Intramucosal cysts in body in 70%, may give rise to fundic gland polyps, severity associated with serum gastrin levels (Hum Pathol 2000;31:140)
Gross description
- Enlarged fundic mucosal folds with cerebriform pattern
Microscopic (histologic) description
- Hyperplasia primarily of parietal cells in fundic glands
- Normal antral glands and gastric pits, often increase in enterochromaffin-like cells
