Stains & CD markers
von Willebrand factor (vWF)
Copyright: 2003-2024, PathologyOutlines.com, Inc.
von Willebrand factor (vWF)
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 12 August 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
Table of Contents
Definition / general | Interpretation | Positive staining - normal | Positive staining - disease | Additional referencesCite this page: Pernick N. von Willebrand factor (vWF). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsvwf.html. Accessed December 28th, 2024.
Definition / general
- Large glycoprotein involved in platelet aggression and adhesion to subendothelial matrix
- Somewhat sensitive (50-75%) for vascular tumors; CD31, CD34 or perhaps FLI1 are more sensitive
Interpretation
- Cytoplasmic stain
- Endothelium should be a positive internal control
Positive staining - normal
- Endothelial cells, megakaryocytes, subendothelial connective matrix
- Areas of tumor necrosis and hemorrhage
Positive staining - disease
- Blood vessels in tumors, vascular tumors, metastatic osteosarcoma
Additional references
