Stains & CD markers
Tyrosinase
Copyright: 2002-2025, PathologyOutlines.com, Inc.
PubMed Search: Tyrosinase[TI] review[ptyp]
Tyrosinase
Author: Lauren N. Stuart, M.D., M.B.A.
Last author update: 1 May 2013
Last staff update: 23 May 2024
Copyright: 2002-2025, PathologyOutlines.com, Inc.
PubMed Search: Tyrosinase[TI] review[ptyp]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Stuart L. Tyrosinase. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainstyrosinase.html. Accessed March 30th, 2025.
Definition / general
- Also called T311 (for immunohistochemistry)
- Melanocyte specific antigen important in melanin synthesis and melanosome formation
- Interpretation: cytoplasmic staining
Uses by pathologists
- Identification of melanocytic neoplasms
Microscopic (histologic) images
Images hosted on other servers:
Normal skin prominent
melanocytes;
melanoma +
homogenous tumor cells
Melanoma
Positive staining - normal
- Melanocytes (Proc Natl Acad Sci U S A 1995;92:8125)
Positive staining - disease
- Melanomas: diffuse reactivity compared to diminished expression towards base in nevi or melanomas with paradoxical maturation; may be useful in evaluating melanomas with extensive necrosis (Am J Clin Pathol 2007;127:787)
- Sinonasal melanomas, oral mucosal melanomas and desmoplastic melanomas (Am J Surg Pathol 2001;25:782)
- Uveal and conjunctival melanomas (Br J Ophthalmol 2012;96:451)
- Other: renal angiomyolipoma (50%, Arch Pathol Lab Med 2007;131:122); PEComas (Int J Surg Pathol 2012;20:29)
Negative staining
- Histiocytic sarcoma (Mod Pathol 2005;18:693)
