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Stains & CD markers
SOX9

Author: Nat Pernick, M.D.

Last author update: 1 November 2013

Last staff update: 23 May 2024

Copyright: 2013-2024, PathologyOutlines.com, Inc.

PubMed Search: SOX9[title]

Table of Contents

Definition / general | Clinical features | Uses by pathologists | Microscopic (histologic) images

Cite this page: Pernick N. SOX9. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainssox9.html. Accessed December 25th, 2024.

Definition / general

Sex determining region Y (SRY)-related high mobility groupbox 9
Transcription factor linked to hedgehog pathways, plays a central role in development and differentiation of multiple cell lineages
Downstream molecule of beta-catenin
Master regulator of chondrogenesis

Clinical features

Poor prognostic factor for colon carcinoma (Am J Clin Pathol 2008;130:897, glioma (Med Oncol 2012;29:3484), hepatocellular carcinoma (Diagn Pathol 2012;7:44), non small cell lung cancer (J Exp Clin Cancer Res 2012;31:18)
Cervix: SOX9 methylation is frequently involved in cervical carcinogenesis (Oncol Rep 2013;29:125)
Prostate: acts as critical downstream effector of ERG in TMPRSS2:ERG fusion+ prostatic adenocarcinoma (J Clin Invest 2013;123:1109)
Soft tissue: expressed in Schwann cells from neurofibromatosis 1 tumors (Hum Pathol 2011;42:434)
Testis: Sertoli cell maturation requires functional androgen/AR signaling to repress SOX9 and AMH expression; impairment of androgen/AR signaling promotes SOX9 mediated AMH production, leading to impairment of Sertoli cells in Sertoli cell only azoospermic patients (PLoS One 2013;8:e76303)