Molecular markers
RET
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 24 October 2022
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: RET
Cite this page: Pernick N. RET. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsret.html. Accessed December 25th, 2024.
Definition / general
- Gene at 10q11.2
- Receptor tyrosine kinase expressed in neural crest cells
- RET ligand is glial-derived neurotrophic factor
- Activating mutations in 90% of patients with MEN 2A and 2B and FMTC (familial medullary thyroid carcinoma)
- Inactivating mutations in Hirschsprung's disease
- RET/PTC gene arrangement is common in papillary thyroid carcinoma; also seen in Hashimoto’s thyroiditis
- Includes RET/PTC1 (60-70%), RET/PTC3 (20-30%)
- Rare families have FMTC & Hirschsprung's, perhaps due to tissue-specific modifiers
Additional references
