Stains & CD markers
Prostein / P501S
Copyright: 2002-2025, PathologyOutlines.com, Inc.
PubMed Search: Prostein [title]
Prostein / P501S
Author: Nat Pernick, M.D.
Last author update: 1 September 2013
Last staff update: 23 May 2024
Copyright: 2002-2025, PathologyOutlines.com, Inc.
PubMed Search: Prostein [title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Prostein / P501S . PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsprostein.html. Accessed April 1st, 2025.
Definition / general
- Also known as p501s, SLC45A3 protein
- Specific marker for benign and malignant prostatic epithelial cells with cytoplasmic staining (Diagn Pathol 2007;2:41, Am J Surg Pathol 2007;31:1351, Prostate 2004;60:246)
- May be down regulated in prostate adenocarcinoma (Int J Cancer 2013;132:807)
Uses by pathologists
- Specific marker for benign and malignant prostatic epithelial cells with cytoplasmic staining (Histopathology 2011;58:750)
- May differentiate prostatic adenocarcinoma from bladder (Diagn Pathol 2011;6:67, Am J Surg Pathol 2008;32:1322, Am J Surg Pathol 2007;31:1246) or colonic carcinomas (Hum Pathol 2007;38:1836)
Microscopic (histologic) images
Images hosted on other servers:
p63 / P501S
Prostate and non-prostatic tissues
Metastatic adenocarcinoma
Various images
Positive staining - normal
- Prostate
Positive staining - disease
- Benign and malignant prostatic epithelial cells
- Prostatic small cell carcinoma (28%, Am J Surg Pathol 2008;32:65)
Negative staining
- Bladder, colonic adenocarcinomas; other non-prostate carcinoma
