Stains & CD markers
NeuN
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: NeuN [title]
NeuN
Author: Nat Pernick, M.D.
Last author update: 1 September 2013
Last staff update: 2 July 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: NeuN [title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. NeuN. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsneun.html. Accessed November 27th, 2024.
Definition / general
- Nuclear protein (neuronal nuclear antigen) widely expressed in mature postmitotic neurons and used as a biomarker for neurons (Wikipedia)
- Is the FOX3 gene product (J Neurosci Methods 2005;148:26)
- Considered a marker of neuronal differentiation in brain tumors; present in all major subtypes except pilocytic astrocytoma
Uses by pathologists
- To determine gray and white matter cell density and cell size (Epilepsia 2007;48:74, Cereb Cortex 2005;15:194)
- May be marker of sudden perinatal death (J Neurol Sci 2013;329:45)
Microscopic (histologic) images
Images hosted on other servers:
Section of cortex
Middle temporal gyral neocortex
Neuronal density changes
Changes in neuronal size
Neuropathological features
Positive staining - normal
- Mature postmitotic neurons
Positive staining - disease
- Amyloid bodies (Morfologiia 2007;131:75)
- Supratentorial pediatric ependymoma (J Neurooncol 2013;112:191)
- Neuroendocrine carcinomas (50 - 90%, Appl Immunohistochem Mol Morphol 2005;13:265)
- Central neurocytomas: NeuN expression correlates with reduced mitotic index (Neuropathol Appl Neurobiol 2005;31:429)
Negative staining
- Cerebellar Purkinje cells and Golgi cells, olfactory Mitral cells, retinal photoreceptors
- No / reduced NeuN expression associated with immature / diseased neurons
- Negative / weak in neurons of substantial nigra (Morfologiia 2013;143:78)
- Pilocytic astrocytoma (Histopathology 2006;48:438), oligodendroglioma (Pathol Res Pract 2003;199:463)
