Stains & CD markers
LMO2
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: LMO2 [title]
LMO2
Author: Nat Pernick, M.D.
Last author update: 1 October 2012
Last staff update: 2 July 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: LMO2 [title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. LMO2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainslmo2.html. Accessed November 27th, 2024.
Definition / general
- LIM-only protein 2
- Germinal center B cell marker (HGAL may be superior)
- Regulatory protein essential for hematopoietic development
- Inappropriate overexpression in T cells contributes to T-cell leukemia
Uses by pathologists
- Differentiate follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LMO2-, Am J Clin Pathol 2009;132:39, Am J Surg Pathol 2010;34:1266)
- Classify difficult cases of follicular lymphoma as part of panel (Appl Immunohistochem Mol Morphol 2013;21:200)
Microscopic (histologic) images
Images hosted on other servers:
Follicular lymphoma LMO2+
Nodal marginal zone lymphoma
Germinal center associated markers
Lymphatic vasculature
CNS vasculature
Benign vascular neoplasms
Malignant vascular neoplasms
Nonvascular malignancies
LMO2 reactivity
Follicular lymphoma
Nodular marginal zone lymphoma
Immunohistologic comparison
Positive staining - normal
- Endothelium and lymphatics, CD34+ blasts, hematopoietic precursors, various B cells (germinal center, mantle, splenic marginal zone)
- Breast myoepithelium, prostatic basal cells, uterine secretory phase endometrial glands
Positive staining - disease
- Follicular lymphoma (Am J Clin Pathol 2011;135:697)
- Hodgkin and Burkitt lymphoma, diffuse large B cell lymphoma-germinal center phenotype (J Egypt Natl Canc Inst 2011;23:147)
- T-ALL, B-ALL
- Usually acute and chronic myeloid leukemia (Histopathology 2012;61:33)
- Neoplastic vessels, including lymphatics, but see below
Negative staining
- Peripheral T cell lymphoma (usually)
- Vasculature is LMO2- in adult and fetal heart, brain of older adults, hepatic sinusoids, and hepatocellular carcinoma (Am J Clin Pathol 2009;131:264)
