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Molecular markers

FGFR

Author: Nat Pernick, M.D.

Last author update: 1 November 2012

Last staff update: 26 October 2022

Copyright: 2003-2024, PathologyOutlines.com, Inc.

PubMed Search: FGFR3

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Table of Contents

Definition / general | Uses by pathologists | Diagrams / tables | Microscopic (histologic) images

Cite this page: Pernick N. FGFR. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsfgfr3.html. Accessed November 27th, 2024.

Definition / general

Member of receptor tyrosine kinase family that controls cell proliferation, differentiation, survival (Cancer Res 2012;72:5843)
Negative regulator of bone growth; mutations lead to increased receptor activation, causing alterations in endochondral ossification in all long bones, including achondroplasia, hypochondroplasia, thanatophoric dysplasia, SADDAN (J Clin Res Pediatr Endocrinol 2012;4:220, Am J Med Genet A 2011;155A:2426)
Mutated in urothelial carcinoma (84% of low grade, 17% of high grade, Hum Pathol 2012;43:1573, J Urol 2012;187:310, J Pathol 2011;224:270), low grade prostatic adenocarcinoma (Mod Pathol 2009;22:848)
Mutated in urothelial papilloma (classic and inverted, Mod Pathol 2009;22:627)
In myeloma, t(4;14) upregulates FGFR3 and myeloma SET domain protein and confers poor prognosis (Blood Cancer J 2012;2:e89)
Activating mutations may cause sytemic epidermal nevi of skin and oral mucosa (BMC Med Genet 2011;12:79)
Regulates Rituximab's inhibitory effect in B cell lymphoma (J Biol Chem 2012;287:37109)

Uses by pathologists

For non muscle invasive urothelial carcinoma, surveillance with FGFR3 mutation analysis on urine to partially replace cystoscopy may be cost-effective (J Urol 2013;189:1676)
Help diagnose upper urinary tract urothelial carcinoma (BMC Urol 2012;12:20)
Help diagnose (with ultrasound) FGFR3-related skeletal dysplasias in utero

Diagrams / tables

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