Stains & CD markers
Fascin
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Fascin[title]
Fascin
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 25 June 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Fascin[title]
Table of Contents
Definition / general | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. Fascin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsfascin.html. Accessed December 21st, 2024.
Definition / general
- 55 kDa protein that forms tight and stable cytoplasmic bundles with filamentous actin
- Fascin-1: most common type; present in specialized cells with extensive surfaces or migratory potential, such as neurons, glia, dendritic cells, macrophages, skeletal and smooth muscle, endothelial cells; not normal epithelial cells
- Fascin-2: in retina
- Fascin-3: in testis
- Actin bundling protein with important role in cell motility and adhesion
- Overexpression in tumors often associated with aggressive disease
Positive staining - disease
- Carcinoma of biliary tract, breast, colon, lung, ovary, pancreas, skin
- Follicular dendritic cell tumors, Hodgkin lymphoma-classic subtype (highly sensitive)
- Interdigitating dendritic cell tumors, Langerhan cell histiocytosis, urothelial carcinoma (noninvasive papillary or invasive)
Negative staining
- Normal epithelial cells, normal urothelium, benign urothelial lesions
Additional references
