Stains & CD markers
Cytokeratin 10 (CK10, K10)
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: CK10
Cytokeratin 10 (CK10, K10)
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 25 June 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: CK10
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Additional referencesCite this page: Pernick N. Cytokeratin 10 (CK10, K10). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsck10.html. Accessed December 24th, 2024.
Definition / general
- Molecular weight of 56.5 kDa
- Partner of CK1
- CK1 and CK10 are present in suprabasal terminally differentiating cells
- Mutations in CK10 or CK1 cause epidermolytic hyperkeratosis / bullous congenital ichthyosiform erythroderma of Brocq (Hum Mol Genet 2006;15:1133, Dermatol Online J 2006;12:6); defects of CK10-CK1 protein network cause structural instability and weakness of keratinocytes, causing blistering, hyperproliferation and hyperkeratosis
- CK10 is putative autoantigen in chronic, antibiotic resistant Lyme arthritis (J Immunol 2006;177:2486)
Uses by pathologists
- Helps distinguish inflammatory linear verrucous epidermal nevus (higher CK10) from psoriasis (Eur J Dermatol 2004;14:216)
- Increase indicates a response to treatment for psoriasis (J Am Acad Dermatol 2004;51:257)
Positive staining - normal
- Epidermal spinous and granular cell layers
Positive staining - disease
- Cervical squamous cell carcinoma-keratinizing (Hum Pathol 2004;35:546)
Additional references
