Stains & CD markers
CAMTA1
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CAMTA1
CAMTA1
Author: Sheren Younes, M.D., Ph.D.
Last author update: 1 May 2016
Last staff update: 23 June 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CAMTA1
Table of Contents
Definition / general | Clinical features | Uses by pathologists | Positive stains | Negative stains | Additional referencesCite this page: Younes, S. CAMTA1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscamta1.html. Accessed November 28th, 2024.
Definition / general
- Calmodulin binding transcription activator 1 (CAMTA1)
- Putative tumor suppressor transcription activator
- Interacts with calmodulin
- Functions as calcium sensitive regulator of gene expression
Clinical features
- CAMTA1 shows deletion in classic oligodendroglial tumors with 1p LOH (Clin Cancer Res 2005;11:1119)
- Deletion from the nervous system of mutant mice results in loss of Purkinje cells, cerebellar atrophy and ataxia (Proc Natl Acad Sci U S A. 2014;111:11521)
Uses by pathologists
- Highly specific and sensitive marker for epitheliod hemangioendothelioma (Histopathology 2015;67:827)
- Most epithelioid hemangioendotheliomas have translocation involving 1p36.3 and 3q25, resulting in WWTR1 - CAMTA1 gene fusion (Sci Transl Med 2011;3:98ra82, Genes Chromosomes Cancer 2011;50:644, Am J Surg Pathol 2001;25:684)
- FISH for WWTR1 - CAMTA1 is a helpful diagnostic tool for epithelioid hemangioendothelioma in small biopsies (Am J Surg Pathol 2015;39:132)
- CAMTA1 IHC differentiates epithelioid hemangioendothelioma from other tumors with epithelioid morphology (Am J Surg Pathol 2016;40:94)
Positive stains
- Staining localization:
- Nuclear
- Normal:
- Higher levels of expression seen in cerebellar granular cell layer
- Expressed also in midbrain, pons, and medulla (Proc Natl Acad Sci U S A 2014;111:11521)
- Disease:
- Epithelioid hemangioendothelioma
- 1 of 37 invasive ductal carcinomas showed CAMTA1 positivity
Negative stains
- Negative in epithelial tumors of bile duct, breast (lobular), endometrium, kidney, liver, lung, ovary, prostate, stomach, thyroid
- Negative in anaplastic large cell lymphoma, angiosarcoma, epithelioid hemangioma, GIST, melanoma, MPNST, myoepithelioma, PEComa, schwannoma, squamous cell carcinoma, synovial sarcoma, urothelial carcinoma
Additional references
