Stains & CD markers
Calponin
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: calponin[title]
Calponin
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 5 August 2024
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: calponin[title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Calponin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscalponin.html. Accessed January 21st, 2025.
Definition / general
- Actin filament associated regulatory protein
- h1 (basic) isoform is smooth muscle specific, but a late stage smooth muscle marker; described below
- h2 isoform is found in smooth muscle and non muscle cells; not described below
Uses by pathologists
- Identify myoepithelial cells in breast lesions (Histopathology 2005;47:202)
- Help differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma (negative, Mod Pathol 2006;19:1351), although adenoid cystic carcinoma is calponin positive in salivary gland tumors (Arch Pathol Lab Med 1999;123:801)
Microscopic (histologic) images
Case #62
Sclerosing lobular hyperplasia
Images hosted on other servers:
Breast:
adenomyoepithelioma
MFH of bone
(fig B, F)
Positive staining - normal
- Smooth muscle, myoepithelial cells (most but not all, Breast Cancer Res 2003;5:R151), myofibroblasts (Am J Surg Pathol 2003;27:82, Proc Natl Acad Sci U S A 1993;90:999); also keratinocytes and nerve fibers (Virchows Arch 2000;437:58), choroidal non-vascular smooth muscle cells (J Anat 2005;207:381)
Positive staining - disease
- Atypical fibroxanthoma (30%, Virchows Arch 2002;440:404), benign fibrous histiocytoma (65%), collagenous spherulosis (Mod Pathol 2006;19:1351), DFSP (40%), fibromatosis (Am J Dermatopathol 2006;28:105), fibrosarcoma (60%), glomus tumor (Am J Surg Pathol 2002;26:301), leiomyoma, leiomyosarcoma, MFH of bone (47%, J Clin Pathol 2002;55:853), MPNST (40%), myoepithelioma-skin, myofibroblastic lesions, myofibroblasts in desmoplastic stroma of carcinomas, nodular fasciitis, solitary fibrous tumor (70%), synovial sarcoma (Histopathology 2003;42:588)
Negative staining
- Adenoid cystic carcinoma
