Alpha-1-antichymotrypsin

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Stains & CD markers
Alpha-1-antichymotrypsin

Author: Nat Pernick, M.D.

Last author update: 1 November 2013

Last staff update: 23 June 2021

Copyright: 2003-2024, PathologyOutlines.com, Inc.

PubMed Search: alpha-1-antichymotrypsin[title]

Table of Contents

Cite this page: Pernick N. Alpha-1-antichymotrypsin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsalpha1antichymo.html. Accessed December 25th, 2024.

Definition / general

Also called α1-ACT
Acute phase protein / plasma protease inhibitor, mainly produced by liver in response to cytokines such as oncostatin M
May limit tissue damage produced by excessive inflammation associated proteolysis
Also localizes to nuclei of hepatic cells to control chromatin condensation and proliferation (Gastroenterology 2013;144:818)
Homologous to alpha-1-antitrypsin
Chymotrypsin is digestive enzyme produced by pancreas

Clinical features

Heart: has role in pathophysiology of heart failure (Circ Heart Fail 2013;6:853)
Kidney: part of plasma molecular profile associated with acute cellular renal allograft rejection (Transplantation 2011;92:388)
Skin: has role in skin repair (J Biol Chem 2011;286:28889)
Umbilical cord: may help differentiate between stillborns and liveborns (Pathol Res Pract 2009;205:534)

Uses by pathologists

Marker for acinic / acinar cell carcinoma in breast (Case Rep Oncol Med 2013;2013:372947), pancreas, salivary gland

Microscopic (histologic) images

Images hosted on other servers:

Breast: primary acinic cell carcinoma (fig F)

Skin: nevi and melanoma

Stomach: hepatoid
adenocarcinoma
(fig C)

Positive staining - normal

Histiocytes, reticulum cells

Positive staining - tumors

Acinic / acinar cell carcinomas of breast, pancreas, salivary gland tumors
Hepatoid adenocarcinoma of stomach (World J Gastroenterol 2013;19:4437)
Solid-pseudopapillay neoplasm of pancreas

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