Stains & CD markers
Neuron specific enolase (NSE)
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Neuron specific enolase
Neuron specific enolase (NSE)
Author: Kara Hamilton, M.S.
Last author update: 1 June 2009
Last staff update: 11 September 2023
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Neuron specific enolase
Table of Contents
Definition / general | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Hamilton K. Neuron specific enolase (NSE). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsNSE.html. Accessed December 21st, 2024.
Definition / general
- Cytoplasmic enzyme expressed by neuroendocrine cells and tumors, including poorly differentiated neuroendocrine tumors, which usually are negative for other neuroendocrine markers
- Despite its name, is often not specific for neuroendocrine cells / tumors
- Enolases are widely distributed glycolytic enzymes that catalyze the interconversion of 2-phosphoglycerate and phosphophenolpyruvate
- NSE refers to the gamma-gamma and alpha-gamma isoenzymes preferentially found in neurons and neuroendocrine cells
Microscopic (histologic) images
Images hosted on other servers:
Pheochromocytoma
Positive staining - normal
- Neurons, neuroendocrine cells
Positive staining - disease
- Neuroectodermal and neuroendocrine neoplasms
- Melanomas
