Stains & CD markers
Lysozyme
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: lysozyme[title]
Lysozyme
Author: Nat Pernick, M.D.
Last author update: 1 June 2012
Last staff update: 2 July 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: lysozyme[title]
Table of Contents
Definition / general | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. Lysozyme. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsLysozyme.html. Accessed November 27th, 2024.
Definition / general
- Also called muramidase
- Histiocytic enzyme that cuts muramic acid linkages in walls of bacterial cells (Wikipedia: Lysozyme [Accessed 3 August 2018])
Microscopic (histologic) images
AFIP images
Orbit: myeloid sarcoma
Thyroid gland: histiocytes stain
Images hosted on other servers:
Acute myelomonocytic leukemia (M4)
Vagina: myeloid sarcoma
Positive staining - normal
- Nonspecific stain for histiocytes (granulomas), monocytes, neutrophils
- May also stain some epithelial cells (pleomorphic adenoma)
- Goblet cells and related lesions (goblet cell carcinoid)
- Breast lactating lobules
Positive staining - disease
- Acinic cell carcinoma (breast, salivary gland, Am J Surg Pathol 2009;33:1137)
- Acute myelomonocytic leukemia (M4), acute monocytic leukemia (M5)
- Adenocarcinoma (various sites)
- Ampulla: Paneth cell carcinoma
- CNS: chordoma
- Eye: oncocytoma of conjunctiva
- Histiocytic lesions: histiocytoma, histiocytic sarcoma, Rosai Dorfman disease
- Langerhans cell histiocytosis
- Mastocytosis
- Myeloid sarcoma
- Renal collecting duct / Bellini duct carcinoma
- Salivary gland intercalated duct lesions (Am J Surg Pathol 2009;33:1322)
- Skin: granuloma annulare, multicentric reticulohistiocytosis, synovial metaplasia, xanthogranuloma
- Spleen: angiosarcoma and hemangioma (often, Mod Pathol 2000;13:978), littoral cell angioma
Negative staining
- Breast: histiocytoid variant of lobular carcinoma
- Dendritic cells
- Inflammatory pseudotumor
- Interdigitating dendritic cell sarcoma
- Skin: necrobiosis lipoidica
