Stains & CD markers
HHV8 / KSHV / LANA
Copyright: 2002-2025, PathologyOutlines.com, Inc.
PubMed Search: HHV8 / KSHV / LANA
HHV8 / KSHV / LANA
Author: Nat Pernick, M.D.
Last author update: 1 May 2013
Last staff update: 22 February 2024
Copyright: 2002-2025, PathologyOutlines.com, Inc.
PubMed Search: HHV8 / KSHV / LANA
Table of Contents
Definition / general | Clinical features | Microscopic (histologic) images | Positive staining - diseaseCite this page: Pernick N. HHV8 / KSHV. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsHHV8.html. Accessed January 7th, 2025.
Definition / general
- Human Herpes Virus 8 is also known as Kaposi’s Sarcoma-associated Herpes Virus
- Gamma herpesvirus identified as an etiologic agent for Kaposi’s sarcoma in 1994
- Latently infects endothelial cells, monocytes and B cells in Kaposi’s sarcoma patients
- HHV8 Latency Associated Nuclear Antigen, highly expressed during latent HHV8 infection, is commonly used for IHC testing
Clinical features
- HHV8 infection is associated with 3 HIV related lymphoproliferative disorders: primary effusion lymphoma, multicentric Castleman’s disease and multicentric Castleman’s disease-associated plasmablastic lymphoma
- IHC is sensitive and specific for Kaposi’s sarcoma but PCR is not due to its presence in other tumors (including hemangiomas) in immunocompromised (may be present within intratumoral blood mononuclear cells, Mod Pathol 2005;18:463)
- LANA interacts with pRb, which regulates beginning of S phase of cell cycle; also inhibits p53
- Presence in serum is associated with developing Kaposi sarcoma in immunocompromised individuals
- References: Am J Surg Pathol 2002;26:1363
Microscopic (histologic) images
Images hosted on other servers:
LANA+ Kaposi sarcoma
Soft tissue, foot: Kaposi sarcoma
Positive staining - disease
- HHV8 associated Kaposi sarcoma (endothelial and spindle cells, 92% sensitive and highly specific), primary effusion lymphoma, multicentric Castleman disease
