Stains & CD markers
Cytokeratin 35 beta H11
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Cytokeratin 8[title]
Cytokeratin 35 beta H11
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 25 June 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: Cytokeratin 8[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - malignant | Negative stainingCite this page: Pernick N. Cytokeratin 35 beta H11. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsCK35bh11.html. Accessed December 2nd, 2024.
Definition / general
- One of several possible clones for CK8
- An antibody to low molecular weight (LMW) cytokeratins - more commonly used LMW antibodies are CAM 5.2, CK8 and AE1
Uses by pathologists
For this clone:
- To distinguish sebaceous carcinoma (35 beta H11+) from squamous cell or basal cell carcinoma (35 beta H11 neg, Pathol Res Pract 1993;189:888)
- To distinguish choroid plexus papilloma (35 beta H11+) from choroid plexus carcinoma (35 beta H11 neg, Arq Neuropsiquiatr 2004;62:600)
Positive staining - normal
- Prostate luminal cells (Virchows Arch A Pathol Anat Histopathol 1992;421:157)
- Skin-sebaceous glands (J Dermatol 1994;21:553)
- Skin-sweat glands (Arch Dermatol Res 1993;285:6)
Positive staining - malignant
- Non-squamous carcinomas including cervical adenocarcinoma (Am J Obstet Gynecol 1992;166:1655)
- Paget’s cells (Gynecol Oncol 1992;46:216)
- Prostate (Virchows Arch A Pathol Anat Histopathol 1992;421:157)
- Sebaceous carcinoma (references above)
Negative staining
- Basal cell and squamous cell carcinoma (references above)
