Soft tissue
Uncertain differentiation
NTRK rearranged spindle cell neoplasm (pending)
Author: Nat Pernick, M.D.
Last staff update: 25 November 2024 (update in progress)
Copyright: 2024, PathologyOutlines.com, Inc.
PubMed Search: NTRK rearranged spindle cell neoplasm
Table of Contents
Definition / generalCite this page: Pernick N. NTRK rearranged spindle cell neoplasm (pending). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuentrkrearranged.html. Accessed November 27th, 2024.
Definition / general
- NTRK rearranged mesenchymal neoplasms show variable morphologic patterns, including lipofibromatosis-like neural tumor, solitary fibrous tumor-like, inflammatory myofibroblastic tumor-like, infantile fibrosarcoma, dermatofibrosarcoma protuberans-like and malignant peripheral nerve sheath tumor-like spindle cell neoplasms and various histologic grades from low to high grade, as well as benign forms (Mod Pathol 2021;34:396)
- Pan-TRK IHC is a reliable diagnostic marker that can be used as a surrogate marker for identification of NTRK fusion in the appropriate setting (young age, morphology) to help discover these rare tumors
- Expensive RNA based next generation sequencing (NGS) to detect / confirm specific fusions needs to be performed if patients are candidates for targeted therapy
- Name may change in the future to kinase rearranged spindle cell neoplasm
- May also have mutations in BRAF, RAF, RET, ALK (Am J Surg Pathol 2018;42:28, Genes Chromosomes Cancer 2018;57:611, Mod Pathol 2021;34:1710)
- See Pan-TRK (EPR17341) [NTRK]
