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Skin nonmelanocytic tumor

Neural tumors

Neurothekeoma

Author: Vijay Shankar, M.D.

Last author update: 1 November 2012

Last staff update: 9 November 2020

Copyright: 2002-2024, PathologyOutlines.com, Inc.

PubMed Search: Neurothekeoma [title] soft tissue

Table of Contents

Cite this page: Shankar V. Neurothekeoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissueneurothekeoma.html. Accessed December 25th, 2024.

Definition / general

Superficial tumor, first described in 1980
Originally, derivation thought to be from nerve sheath; now thought to derive from fibroblasts with ability to differentiate into myofibroblasts and to recruit histiocytes (Am J Surg Pathol 2007;31:1103)

Sites

Usually head, upper extremities or shoulder girdle

Clinical features

Solitary, superficial, slow growing mass up to 2 cm
60% women, mean age 17 years (range 2 - 85 years), 80% are < age 30 at initial diagnosis

Case reports

5 month old boy with thumb swelling (Indian J Dermatol 2009;54:59)
19 year old woman with painful subcutaneous nodule on lower back (Dermatol Online J 2009;15:3)
66 year old man with painless swelling in eyelid (Indian J Ophthalmol 2008;56:334)

Treatment

Excision, may recur

Clinical images

Images hosted on other servers:

Thumb nodule

Lower back

Lower eyelid

Microscopic (histologic) description

Cellular, myxoid or mixed subtypes
Involves dermis or subcutis
Multinodular mass with myxoid matrix and peripheral fibrosis
Whorled or focally fascicular patterns of spindled and epithelioid mononuclear cells with abundant cytoplasm, indistinct cell borders
Margins usually positive; usually occasional multinucleated giant cells
Variable nuclear atypia
Median 4 MF / 25 HPF, may have 10+ MF / 25 HPF, may be atypical

Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.