Small intestine & ampulla
Benign tumors / tumor-like conditions
Lymphoid hyperplasia
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 August 2012
Last staff update: 19 April 2021
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: Lymphoid hyperplasia[TI] small bowel
Table of Contents
Definition / general | Case reports | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosisCite this page: Gulwani H. Lymphoid hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/smallbowellymphoidhyperplasia.html. Accessed March 30th, 2025.
Definition / general
- Also called lymphoid polyp; formerly called pseudolymphoma
- Most common site is ileocecal region
- Causes intussusception in children
- Nodular lymphoid hyperplasia: nodules throughout bowel, associated with giardiasis or childhood viral infection
Case reports
- 60 year old woman with florid reactive lymphoid hyperplasia of terminal ileum (BMJ Case Rep 2010;2010)
Gross images
Images hosted on other servers:
Terminal ileum exhibiting
shows mucosal ulcers
due to nodular lymphoid
hyperplasia
Microscopic (histologic) description
- Numerous lymphoid follicles with germinal centers in lamina propria or submucosa
Microscopic (histologic) images
Images hosted on other servers:
Various images
Positive stains
- CD20, CD45; do not confuse BCL2 expression in marginal zone cells with BCL2 expression of germinal center cells in follicular lymphoma (Am J Surg Pathol 2003;27:888)
Differential diagnosis
- Low grade lymphoma: often infiltrative, light chain restriction
