Skin nonmelanocytic tumor
Vascular tumors
Intravascular papillary endothelial hyperplasia
Author: Christopher S. Hale, M.D.
Last author update: 1 July 2012
Last staff update: 6 November 2020
Copyright: 2001-2024, PathologyOutlines.com, Inc.
PubMed search: intravascular papillary endothelial [title] hyperplasia
Related topic: Soft tissue chapter
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Hale C. Intravascular papillary endothelial hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticintravascularpapillary.html. Accessed November 27th, 2024.
Definition / general
- Also called Masson hemangioma (Am J Dermatopathol 2003;25:71)
- Often on fingers and in hemorrhoids
- In skin, associated with preexisting pyogenic granuloma or hemangioma, vascular malformations or hemangiomas of blue rubber bleb nevus syndrome
- Due to exuberant recanalization of a thrombus
- May be secondary to trauma or superimposed on pyogenic granuloma or cavernous hemangioma
- Slow growing, tender, blue red, deep dermal to subcutaneous mass
- Rarely recurs after excision
Case reports
- 70 year old woman with 1 cm lesion on buccal mucosa (Case Rep Dermatol 2010 2;1:22)
Microscopic (histologic) description
- Dilated vessel contains papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue
- Fibrin deposition and thrombi present
- Variable pleomorphism and stratification, no/rare mitotic figures, no necrosis, no solid cellular areas
Microscopic (histologic) images
Images hosted on other servers:
Histological features of IPEH
Differential diagnosis
- Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen
