Skin nonmelanocytic tumor
Adnexal tumors
Hair follicles
Fibrofolliculoma / trichodiscoma
Author: Christopher S. Hale, M.D.
Last author update: 1 June 2012
Last staff update: 11 November 2024 (update in progress)
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Hamartoma of hair follicle
Table of Contents
Definition / general | Case reports | Clinical images | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Hale CS. Fibrofolliculoma / trichodiscoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticfolliculofibroma.html. Accessed November 27th, 2024.
Definition / general
- Considered a hamartoma of hair follicle
Birt-Hogg-Dubé syndrome
- Folliculofibroma associated with Birt-Hogg-Dubé (BHD) syndrome
- Autosomal dominant, multiple folliculomas on head and neck, acrocordons and trichodiscomas; also renal cell carcinoma [various types], renal oncocytoma and oncocytic hybrid tumors, lung cysts and spontaneous pneumothorax)
- Human gene at 17p11.2 encodes folliculin, normally expressed in skin and adnexae (Mod Pathol 2004;17:998)
- Frameshift mutations occur in BHD causing premature protein termination
Case reports
- 54 year old man with papules on cheeks (Ann Dermatol 2011;23:S193)
Clinical images
Images hosted on other servers:
Various images
Gross description
- Multiple skin-colored papules
Microscopic (histologic) description
- Thin epidermal strands originating from a central hair follicle with prominent connective tissue
Microscopic (histologic) images
Images hosted on other servers:
Various images
Differential diagnosis
- Mantleoma
- Perifollicular fibroma
- Trichodiscoma
- Trichofolliculoma
