Skin melanocytic tumor
Nevi
Combined (clonal, blue, PEM, DPN, BAP1 and Spitz)
Author: Christopher S. Hale, M.D.
Last author update: 1 March 2013
Last staff update: 1 November 2023
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: skin melanocytic tumor combined nevus
Table of Contents
Definition / general | Terminology | Epidemiology | Sites | Clinical features | Clinical images | Case reports | Microscopic (histologic) images | Positive stainsCite this page: Hale CS. Combined (clonal, blue, PEM, DPN, BAP1 and Spitz). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumormelanocyticcombinednevus.html. Accessed November 27th, 2024.
Definition / general
- Uncommon; two types of melanocytic proliferation in same pigmented lesion (Am J Surg Pathol 1991;15:1111)
- Usually common blue nevus of penetrating type and acquired nevus (Pathology 2004;36:419)
- Rarely includes Spitz nevus, which are difficult to classify by dermoscopy (J Cutan Pathol 2004;31:600)
Terminology
- Also called melanocytic nevus with phenotypic heterogeneity
Epidemiology
- Mean age 30 years
Sites
- Usually trunk, head and neck and upper extremity
Clinical features
- May resemble melanoma, particularly at dermoscopy (Dermatology 2007;214:174, Dermatol Surg 2006;32:1176)
Clinical images
Images hosted on other servers:
Globular pattern
associated with a
central homogenous
pattern (darker area)
Case reports
- Common blue nevus and pigmented epithelioid melanocytoma (J Am Acad Dermatol 2008;58:1021)
- Compound nevus and spindle cell Spitz nevus (J Dermatol 2000;27:233)
- Cellular blue nevus in reticular dermis, overlying compound melanocytic nevus with transition to melanoma in situ (Am J Dermatopathol 1991;13:169)
Microscopic (histologic) images
Images hosted on other servers:
Spitz nevus and common nevus
Positive stains
- S100, MelanA and HMB45 may be variable (J Dermatol 2000;27:233)
