Skin nontumor
Vesiculobullous and acantholytic reaction patterns
Subcorneal pustular dermatosis
Last author update: 1 July 2011
Last staff update: 31 July 2020
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PubMed Search: Subcorneal pustular dermatosis [title]
Table of Contents
Definition / general | Terminology | Epidemiology | Clinical features | Treatment | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosis | Additional referencesCite this page: Hamodat M. Subcorneal pustular dermatosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumorsubcornealpustulardermatosis.html. Accessed January 4th, 2025.
Definition / general
- Rare, recurrent, noninfective, nonautoimmune pustular eruption of unknown etiology
Terminology
- Also called Sneddon-Wilkinson disease
Epidemiology
- Associated with benign or malignant IgA paraproteinemia, rheumatoid arthritis, SLE, bullous pemphigoid, squamous cell carcinoma of the bronchus and metastatic gatrinomas
Clinical features
- Large pustules on trunk and body folds
Treatment
- Dapsone as first-like treatment; acitretin for nonresponders to dapspone (J Dermatolog Treat 2010;21:114)
Clinical images
Images hosted on other servers:
Symmetric and diffusely scattered vesicopustules on trunk and extremities
Microscopic (histologic) description
- Large unilocular subcorneal pustule containing a small amount of neutrophils and minimal acantholysis
- May be psoriasiform
- Superficial dermis has neutrophils and lymphocytes
Microscopic (histologic) images
Images hosted on other servers:
Subcorneal pustule containing a few neutrophils and acantholytic cells
Differential diagnosis
- Impetigo
- Pustular psoriasis
- Staphylococcal scalded skin syndrome (SSSS)
Additional references
