Salivary glands
Nonneoplastic tumors / tumor-like conditions
Intercalated duct hyperplasia
Last author update: 1 October 2015
Last staff update: 20 January 2025 (update in progress)
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PubMed Search: Intercalated duct hyperplasia
Table of Contents
Definition / general | Microscopic (histologic) description | Additional referencesCite this page: Tanakchi S Intercalated duct hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/salivaryglandsADH.html. Accessed April 3rd, 2025.
Definition / general
- Incidental microscopic finding (70% incidence) during histologic examination of a salivary gland tumor
- Predominates in male patients (3:1) in sixth decade of life
- More frequent in parotid compared to submandibular gland (3:1)
- Hypothesized to be a precursor lesion of salivary gland tumor, especially epithelial myoepithelial carcinoma
Microscopic (histologic) description
- Proliferating ducts admixed with acinar cell complexes
- Ducts are frequently lined with single layer of cells; on occasion, may have luminal and abluminal lining cells
- Acinar cells are characterized by atrophic changes (loss of zymogen granules, decrease in cell volume) resulting in morphologic resemblance to intercalated ducts
Additional references
