Prostate gland & seminal vesicles
Nonneoplastic
Verumontanum mucosal hyperplasia
Author: Andres Matoso, M.D.
Last author update: 1 September 2015
Last staff update: 9 January 2020
Copyright: 2003-2020, PathologyOutlines.com, Inc.
PubMed Search: Verumontanum mucosal hyperplasia
Table of Contents
Definition / general | Sites | Clinical features | Diagnosis | Case reports | Treatment | Microscopic (histologic) description | Positive stains | Differential diagnosis | Additional referencesCite this page: Matoso A. Verumontanum mucosal hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/prostateverumonthyper.html. Accessed January 3rd, 2025.
Definition / general
- Well circumscribed small acinar proliferation in or adjacent to verumontanum and posterior prostatic urethra
Sites
- The verumontanum is located in the posterior aspect of the prostatic urethra
- It is the area where the utricle and the ejaculatory ducts merge with the urethra
Clinical features
- The presence of verumontanum mucosa gland hyperplasia is an asymptomatic morphologic variant of the glands underlying the posterior wall of the prostatic urethra
Diagnosis
- Can be identified in TURP specimens or in needle biopsies of the prostate
Case reports
- 5 cases of verumontanum mucosal gland hyperplasia in prostatic needle biopsy specimens (Am J Clin Pathol 1995;104:620)
Treatment
- Not required
Microscopic (histologic) description
- Crowded small acinar proliferation, usually arranged in a well circumscribed nodule
- The glands can have intraluminal concretions that vary in color from orange to gray or green
- May be seen underlying the urethral urothelium
Positive stains
- The immunophenotype is identical to normal prostate glands, including basal cell markers
Differential diagnosis
- Verumontanum mucosal gland hyperplasia (VMGH), when present in a prostate needle biopsy, could be mistaken for low grade prostatic adenocarcinoma (Gleason pattern 3)
- The lobular architecture and the presence of basal cells are features to differentiate it from Gleason pattern 3 cancer
- Another helpful feature is the presence of corpora amylacea or the orange-grey-green concretions that are features of VMGH and not of prostatic carcinoma
- Occasionally, it can present with a papillary architecture simulating prostatic duct adenocarcinoma
- In contrast to prostatic duct carcinoma, the cells in VMGH are more cuboidal and without nuclear atypia
Additional references
