Prostate gland & seminal vesicles
Acinar / ductal adenocarcinomas
Acinar adenocarcinoma
Mucinous (colloid) pattern
Author: Komal Arora, M.D.
Last author update: 1 March 2012
Last staff update: 21 November 2023
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed search: prostatic mucinous adenocarcinoma
Table of Contents
Definition / general | Microscopic (histologic) description | Positive stains | Differential diagnosisCite this page: Arora K. Mucinous (colloid) pattern. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/prostatemucinous.html. Accessed December 27th, 2024.
Definition / general
- Uncommon (< 1%)
- Intra and extracellular mucin must comprise 25%+ of tumor
- May be more hormone independent, less responsive to radiation therapy
- Aggressive biologic behavior (Am J Surg Pathol 1985;9:299, Am J Surg Pathol 2008;32:468, Mod Pathol 2004;17:316)
Microscopic (histologic) description
- Tumor cells float in pools of mucin
- Resembles mucinous (colloid) carcinoma of breast
- Has microglandular, cribriform, comedo, solid and hypernephroid patterns
- Signet ring cells are rare
Positive stains
- PSA, PAP, MUC2 (Mod Pathol 2008;21:789)
Differential diagnosis
- Extension of large bowel carcinoma, Cowpers gland carcinoma
- Mucinous adenocarcinoma of bladder (PSA-, PAP+)
- Post-hormone treatment changes which leave behind acellular pools of mucin (Am J Surg Pathol 1998;22:347)
