Ovary
Sex cord stromal tumors
Pure stromal tumors
Fibrosarcoma
Author: Nalini Gupta, M.D.
Last author update: 1 June 2016
Last staff update: 11 December 2024
Copyright: 2003-2025, PathologyOutlines.com, Inc.
PubMed Search: fibrosarcoma [title] ovary
Table of Contents
Definition / general | Epidemiology | Clinical features | Laboratory | Radiology description | Prognostic factors | Case reports | Treatment | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Cytology images | Positive stains | Negative stains | Molecular / cytogenetics description | Differential diagnosisCite this page: Gupta N. Fibrosarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorfibrosarcoma.html. Accessed April 2nd, 2025.
Definition / general
- Very rare (< 100 reported cases) aggressive tumor which arises directly from stromal cells or from preexisting cellular fibroma
- More common in bone
Epidemiology
- Median age 49 years, range 20 - 73 years
Clinical features
- Pelvic pain, abdominal enlargement, awareness of abdominal mass (Cancer 1981;47:2663)
Laboratory
- CA125 and CEA in normal range
Radiology description
- MRI: solid mass (Anticancer Res 2007;27:4365)
Prognostic factors
- FIGO stage (BMC Cancer 2010;10:585)
Case reports
- 8 year old girl with nevoid basal cell carcinoma syndrome (Am J Surg Pathol 1984;8:231)
- 32 year old woman (Anticancer Res 2007;27:4365)
- 52 year old woman (Int J Gynecol Cancer 2005;15:1142)
Treatment
- Surgical resection with or without adjuvant chemotherapy or radiation
Gross description
- 5 - 23 cm solid mass, tan-yellow discoloration and partial necrosis (BMC Cancer 2010;10:585)
Gross images
Images hosted on other servers:
Capsular disruption and hemorrhage
Microscopic (histologic) description
- Spindle cells arranged in sheets and intersecting fascicles creating a diffuse herringbone appearance
- Mild to moderate nuclear atypia
- Reticulin stain separates individual neoplastic cells
- Mitotic activity > 4/10 HPF is most important criteria for diagnosing fibrosarcoma
Microscopic (histologic) images
AFIP images
Moderate cytologic atypia
Cytology description
- Pleomorphic oval to spindle shaped cells with indistinct cell borders and atypical mitotic figures
Cytology images
Images hosted on other servers:
Clusters of pleomorphic spindle cells
Positive stains
Molecular / cytogenetics description
- Trisomy 8 present, may be helpful in distinguishing from cellular fibroma (Am J Surg Pathol 1997;21:52)
Differential diagnosis
- Cellular fibroma: mitotic activity < 3/10 HPF, no trisomy 8 (Am J Surg Pathol 1997;21:52)
