Lung
Noninfectious granulomatous inflammation
Bronchocentric granulomatosis
Author: Elliot Weisenberg, M.D.
Last author update: 1 September 2011
Last staff update: 18 March 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed search: bronchocentric granulomatosis
Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Differential diagnosisCite this page: Weisenberg E. Bronchocentric granulomatosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lungnontumorbronchocentric.html. Accessed December 2nd, 2024.
Definition / general
- Granulomatous disease of lungs in which almost all granulomas are centered in bronchi or bronchioles causing their destruction
- Immunologic reaction related to chronic eosinophilic pneumonia and allergic bronchopulmonary aspergillosis
- A histologic pattern of disease, not a specific diagnosis
- Usually adults, often with asthma history and limited to lungs, may be asymptomatic
- Usually solitary lesions that appear on chest Xray as atelectasis or consolidation, not nodules
- Generally favorable prognosis
Gross description
- Viscous material in involved bronchi
Microscopic (histologic) description
- Large and medium bronchi infiltrated by neutrophils, eosinophils and necrotic debris surrounded by foreign body giant cells
- Fragmented elastic tissue (with elastic stain)
- Also bronchiolitis obliterans
- No fibrinoid necrosis of vessels
Differential diagnosis
- Granulomatosis with polyangiitis (Wegener's): kidney involvement, may also have bronchocentric granulomas
- Rheumatoid arthritis
- Tuberculosis
- Fungi: can identify orgqanisms with silver stain
- Cystic fibrosis: different clinical history
