Liver & intrahepatic bile ducts
Benign / nonneoplastic
Reactive lymphoid hyperplasia / pseudolymphoma
Author: Deepali Jain, M.D.
Last author update: 1 February 2012
Last staff update: 17 March 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Reactive lymphoid hyperplasia pseudolymphoma liver
Table of Contents
Definition / general | Case reports | Gross description | Microscopic (histologic) description | Positive stains | Negative stains | Differential diagnosisCite this page: Jain D. Reactive lymphoid hyperplasia / pseudolymphoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/livertumorreactivelymphoid.html. Accessed December 23rd, 2024.
Definition / general
- Also called pseudolymphoma, may mimic lymphoma (Mod Pathol 2010;23:244, Am J Surg Pathol 1999;23:302)
- Rare, < 50 cases reported
- Age range 15 - 81 years; female predominance
- Usually incidental finding, right lobe predilection
- Associated with chronic liver disease, extrahepatic autoimmune disorders and malignancies
- May be concomitant hepatic and pancreatic involvement (Clin Res Hepatol Gastroenterol 2012;36:e71)
- May be immune mediated
- No associated systemic manifestations
- Resection is curative
Case reports
- 69 year old woman with stage I renal cell carcinoma and hepatic mass (Arch Pathol Lab Med 2001;125:577)
Gross description
- Well circumscribed, tan, nonencapsulated, solitary (multiple in 20%) rubbery nodule, 0.5 - 5.5 cm
Microscopic (histologic) description
- Prominent lymphoid follicles with germinal centers, tingible body macrophages and polymorphic small lymphocytes
Positive stains
Negative stains
- BCL2 does not stain germinal centers; no light chain restriction
Differential diagnosis
- Autoimmune hepatitis
- Castleman disease
- Chronic hepatitis B or hepatitis C infection
- MALT or other low grade lymphoma: lymphoepithelial lesions, cellular atypia, light chain restriction
- Primary biliary cirrhosis
