Fallopian tubes & broad ligament
General
WHO classification
Author: Gulisa Turashvili, M.D., Ph.D.
Editorial Board Member: Ricardo R. Lastra, M.D.
Deputy Editor-in-Chief: Jennifer A. Bennett, M.D.
Last author update: 2 September 2022
Last staff update: 2 September 2022
Copyright: 2022, PathologyOutlines.com, Inc.
PubMed Search: WHO classification of fallopian tube
Table of Contents
Definition / general | Major updates | WHO (2020) - fallopian tube | WHO (2020) - broad ligament and other uterine ligaments | Microscopic (histologic) images | Additional references | Board review style question #1 | Board review style answer #1 | Board review style question #2 | Board review style answer #2Cite this page: Turashvili G. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/fallopianwhoclassification.html. Accessed January 11th, 2025.
Definition / general
- WHO classification of tumors of the female genital tract
- Currently on 5th edition, published in 2020
Major updates
- No major updates, mostly refined definitions
- Most high grade serous carcinomas of the ovary arise at the fimbriated end of the fallopian tube from a precursor lesion known as serous tubal intraepithelial carcinoma (STIC) (Pathology 2015;47:423, Mod Pathol 2015;28:1101)
- Undifferentiated carcinoma of the fallopian tube is no longer a separate category
WHO (2020) - fallopian tube
-
Epithelial tumors ICD-O
- Serous adenofibroma, NOS9014/0
- Serous borderline tumor, NOS8442/1
- High grade serous carcinoma8461/3
- Endometrioid adenocarcinoma, NOS 8380/3
- Carcinosarcoma, NOS8980/3
-
Tumor-like lesions
- Paratubal cysts
- Tubal hyperplasia
- Tubo-ovarian abscess
- Salpingitis isthmica nodosa
- Metaplastic papillary lesion
- Placental site nodule
- Mucinous metaplasia
- Endosalpingiosis
-
Mixed epithelial and mesenchymal tumors
- Adenosarcoma8933/3
-
Germ cell tumors
- Mature teratoma, NOS9080/0
- Immature teratoma, NOS9080/3
WHO (2020) - broad ligament and other uterine ligaments
-
Mesenchymal and mixed tumors ICD-O
- Leiomyoma, NOS8890/0
- Adenomyoma, NOS8932/0
- Adenosarcoma8933/3
- Leiomyosarcoma, NOS8890/3
-
Miscellaneous tumors
- Wolffian tumor9110/1
- Papillary cystadenoma, NOS8450/0
- Ependymoma, NOS9391/3
-
Tumor-like lesions
- Adrenocortical remnants
Microscopic (histologic) images
Contributed by Gulisa Turashvili, M.D., Ph.D.
STIC associated with invasion
Endometrioid adenocarcinoma
Salpingitis isthmica nodosa
Additional references
Board review style question #1
What is a precursor lesion of most high grade serous carcinomas?
- Low grade serous carcinoma
- Ovarian cortical inclusion cysts
- Paratubal cyst
- Serous borderline tumor
- Serous tubal intraepithelial carcinoma (STIC)
Board review style answer #1
E. Serous tubal intraepithelial carcinoma (STIC)
Comment Here
Reference: Fallopian tubes & broad ligament - WHO classification
Comment Here
Reference: Fallopian tubes & broad ligament - WHO classification
Board review style question #2
What is the most likely diagnosis for this salpingectomy specimen?
- Focal tubal hyperplasia
- High grade serous carcinoma
- High grade serous carcinoma and serous tubal intraepithelial carcinoma (STIC)
- Low grade serous carcinoma
- Serous tubal intraepithelial carcinoma (STIC)
Board review style answer #2
C. High grade serous carcinoma and serous tubal intraepithelial carcinoma (STIC)
Comment Here
Reference: Fallopian tubes & broad ligament - WHO classification
Comment Here
Reference: Fallopian tubes & broad ligament - WHO classification
