Coagulation
Coagulation laboratory tests
Reptilase time
Author: Jeremy C. Parsons, M.D.
Last author update: 1 November 2012
Last staff update: 23 September 2020
Copyright: 2002-2025, PathologyOutlines.com, Inc.
PubMed Search: Reptilase time [title]
Table of Contents
Definition / generalCite this page: Parsons JC. Reptilase time. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationreptilasetime.html. Accessed January 10th, 2025.
Definition / general
- Clotting time similar to thrombin time, but uses snake venom (reptilase) instead of thrombin
- Measure rate of fibrin clot formation after addition of reptilase to citrated plasma
- Generates a fibrin clot by cleaving fibrinopeptide A from fibrinogen
- Prolonged by decreased or dysfunctional fibrinogen, or high levels of fibrin degradation products; also amyloidosis (inhibits fibrinogen conversion to fibrin); also prolonged by increased fibrinogen associated with acute phase reaction (Am J Clin Pathol 2002;118:263)
- Used to diagnose dysfibrinogenemia (also thrombin time)
- Not prolonged by heparin or hirudin (unlike thrombin time)
