Coagulation
Acquired bleeding disorders
Liver dysfunction
Author: Nat Pernick, M.D.
Last author update: 1 June 2012
Last staff update: 23 September 2020
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Liver dysfunction [title] coagulation
Table of Contents
Definition / generalCite this page: Pernick N. Liver dysfunction. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/coagulationliverdysfunction.html. Accessed November 28th, 2024.
Definition / general
- Liver is site of production of most coagulation factors, but response of each factor to liver disease is variable due to differences in biologic half lives and acute phase reactions
- PT usually prolonged first, then PTT
- Factor VII: shortest biologic half life, often affected earliest with largest decrease in serum level
- Factor VII also decreases earliest with warfarin treatment
- Factor VIII: may be normal or elevated due to acute phase reaction
- Factors XI and XII: long biologic half lives, may be normal until liver disease is advanced
