CNS & pituitary tumors
Meningeal tumors
Rhabdoid meningioma
Last author update: 1 March 2014
Last staff update: 9 August 2023
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Rhabdoid meningioma [title]
Table of Contents
Definition / general | Sites | Radiology description | Radiology images | Case reports | Treatment | Gross description | Microscopic (histologic) description | Cytology description | Cytology images | Positive stains | Negative stains | Electron microscopy description | Differential diagnosisCite this page: Kresak J, Yachnis A. Rhabdoid meningioma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumorrhabdoidmeningioma.html. Accessed November 27th, 2024.
Definition / general
- WHO grade 3 due to aggressive behavior and metastatic potential
- High rate of recurrence
- Rhabdoid morphology may increase with recurrences
Sites
- May be supratentorial, infratentorial or spinal
Radiology description
- MRI may show irregular tumor borders, cystic component, heterogenous tumoral enhancement and peritumoral edema suggesting a high grade meningioma (AJNR Am J Neuroradiol 2007;28:1462)
Radiology images
Images hosted on other servers:
Marked enhancing mass at left frontal lobe
Hyperostosis, bony erosion in right anterior clinoid process
Tumor in right infratemporal fossa
Lesion was isointense on T1 and T2 weighted images
Avidly enhancing, complex falcine meningioma
Case reports
- 8 year old girl (Med Arh 2010;64:123) and 15 year old boy (Am J Surg Pathol 2001;25:964)
- 47 year old woman with recurrent tumor (Skull Base 2003;13:51)
- 55 year old woman with intraventricular tumor (J Clin Neurosci 2007;14:672)
- 60 year old man with recurrent extracerebral tumor (University of Pittsburgh: A Male in His Late 60's with Recurrent Extracerebral Tumor)
- Lacking malignant features (Clin Neuropathol 2004;23:16)
- Intraspinal tumor with metastasis to liver (J Clin Neurosci 2011;18:714)
Treatment
- Gross total resection
- Postsurgical radiotherapy (Front Oncol 2013;3:227)
- Radiosurgery (Radiat Oncol 2014;9:38)
Gross description
- Dural based
- May be well circumscribed or readily adherent to brain parenchyma
- Size can vary
Microscopic (histologic) description
- Sheets of loosely cohesive cells with eccentric nuclei and hyaline, paranuclear inclusions
- Nuclei may show pleomorphism, with vesicular chromatin and prominent nucleoli
- May retain meningothelial features including whorl formation and nuclear pseudoinclusions
- May have brain invasion
- Often increased mitotic activity (greater than 4/10 HP)
- May have papillary features
Cytology description
- Rhabdoid cells with abundant eosinophilic cytoplasm, cytoplasmic hyaline inclusions, eccentric nuclei
- Stout processes consistent with meningioma; however distinct cell borders
- Often vesicular nuclei with prominent nucleoli
- May see mitoses on smear
- May see pseudonuclear inclusions (Diagn Cytopathol 2010;38:594)
Cytology images
Images hosted on other servers:
Squash prep 40x
Positive stains
- EMA (variable), PR (in a subset; helpful if positive, not ruled out if negative), vimentin
- INI1 (Mod Pathol 2005;18:951)
- Cytokeratins may pick up cytoplasmic inclusions
- Ki67 (often 10% or more)
Negative stains
Electron microscopy description
- Cytoplasmic whorls of intermediate filaments often entrapping lysosomes or other organelles
- Interdigitating cell membranes and intercellular junctions
Differential diagnosis
