CNS & pituitary tumors
Pineal tumors
Pineal parenchymal tumor of intermediate differentiation
Author: Nat Pernick, M.D.
Last author update: 1 January 2006
Last staff update: 18 August 2020
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Pineal parenchymal tumor of intermediate differentiation
Table of Contents
Definition / general | Microscopic (histologic) description | Molecular / cytogenetics description | Additional referencesCite this page: Pernick N. Pineal parenchymal tumor of intermediate differentiation. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cnstumorpinealparenchymalintermediate.html. Accessed November 27th, 2024.
Definition / general
- Features intermediate between pineocytoma and pineoblastoma
- 10% of pineal parenchymal tumors
- Occasionally associated with CNS or extraneural metastasis but otherwise difficult to predict prognosis
- Better survival than pineoblastoma
Microscopic (histologic) description
- Marked hypercellularity but relatively bland nuclear features
- No / mild nuclear pleomorphism
- No / rare pinocytomatous rosettes
- Minimal mitotic activity
Molecular / cytogenetics description
- Often +4q, +12q, -22 (Genes Chromosomes Cancer 2001;30:99)
Additional references
