Cervix
Other tumors
Metastases
Authors: Branko Perunovic, D.M., Marilin Rosa, M.D.
Last author update: 1 May 2007
Last staff update: 10 June 2024
Copyright: 2007-2024, PathologyOutlines.com, Inc.
PubMed Search: "metastatic to" cervix
Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Cytology description | Cytology images | Immunohistochemistry & special stainsCite this page: Perunovic B, Rosa M. Metastases. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixmets.html. Accessed December 24th, 2024.
Definition / general
- Extragenital tumors more commonly metastasize to ovary and vagina than cervix
- Usually from ovary, breast, colon (Arch Pathol Lab Med 2003;127:1586), stomach, kidney; evidence of widespread disease is usually present
- Direct extension from endometrial primary tumor is also common (particularly poorly differentiated adenocarcinoma)
- Often involves cervical stroma and NOT surface epithelium or endocervical glands
- Rarely due to metastatic mucinous carcinoma of appendix
Case reports
- 17 year old with colon cancer metastatic to cervix presenting with abnormal pap smear (J Reprod Med 2005;50:793)
- 19 year old girl with renal cell carcinoma metastasis (Gynecol Oncol 2005;99:232)
- 59 year old with recurrent colon carcinoma invading into uterus and cervix and presenting with HSIL at pap smear (J Low Genit Tract Dis 2005;9:236)
- 61 year old with metastatic salivary duct carcinoma (Diagn Cytopathol 1999;21:271)
- 71 year old woman with signet ring breast metastases (Gynecol Oncol 1998;71:461)
- Gastric carcinoma (Int J Gynecol Cancer 2003;13:555)
- Uterine metastases from breast cancer patient on tamoxifen (Eur J Gynaecol Oncol 1999;20:416)
Microscopic (histologic) description
- Usually no in situ component
- Extensive angiolymphatic invasion is present, even in small and superficial lesions
Microscopic (histologic) images
AFIP images
Breast carcinoma metastatic to cervix
Case #125 (metastatic lobular carcinoma to endometrial polyp)
Various images
ER
PR
GCDFP-15
Cytology description
- Yield for positive Pap smear diagnoses in extrauterine malignancies is best in patients with an established diagnosis (Acta Cytol 1999;43:806)
Cytology images
Contributed by Carmen Luz, M.D.
Ovarian clear cell carcinoma
Immunohistochemistry & special stains
- Immunohistochemistry panels will vary according to site of origin
- Clinical history important when selecting panels of immunostains
