Cervix
Other tumors
Lymphoma
Author: Branko Perunovic, D.M.
Last author update: 1 May 2007
Last staff update: 28 January 2025 (update in progress)
Copyright: 2007-2025, PathologyOutlines.com, Inc.
PubMed Search: Lymphoma cervix
Table of Contents
Definition / general | Clinical features | Case reports | Gross description | Microscopic (histologic) description | Cytology description | Cytology images | Differential diagnosisCite this page: Perunovic B. Lymphoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixlymphoma.html. Accessed April 3rd, 2025.
Definition / general
- Primaries are rare in cervix (< 100 cases reported)
Clinical features
- Mean age approximately 40 years; range 20's to 80's
- Usually presents with abnormal uterine or vaginal bleeding
- Cervical smear may be first indication of tumor but smear is often negative or reported as SIL
- Most cases present with stage IE disease (Am J Obstet Gynecol 2005;193:866)
- Usually diffuse large B cell lymphoma or follicular lymphoma (Mod Pathol 2000;13:19)
- 5 year survival: 83% in low stage tumors, 29% in high stage tumors
- Should confirm with immunostains to rule out other unusual tumors and to classify
Case reports
- 30 and 45 year old women with NK lymphoma (Arch Pathol Lab Med 2000;124:1510)
- 32 year old woman with sarcomatoid variant of B cell lymphoma (Int J Gynecol Pathol 2003;22:289)
- 38 year old woman with precursor T cell acute lymphoblastic leukemia/lymphoma (Ann Diagn Pathol 2002;6:125)
- 42 year old woman with Burkitt lymphoma with HSIL (Pathol Res Pract 2005;201:521)
- 46 year old woman with MALT lymphoma presenting as endocervical polyp (Arch Pathol Lab Med 2001;125:537)
- 49 and 51 year old women with HSIL by pap smear and diffuse large B cell lymphoma and follicular lymphoma (Gynecol Oncol 2005;98:484)
- 51 year old woman with relapse in cervix (Leuk Lymphoma 2002;43:203)
- 52 year old woman with squamous cell carcinoma (Gynecol Oncol 2004;92:974)
- Detection of HTLV1 in adult T cell leukemia/lymphoma by PCR on cytologic smears (Methods Mol Biol 2005;304:183)
- Two patients with primary diffuse large B cell lymphoma (Eur J Gynaecol Oncol 2005;26:36)
- Two patients with diffuse large B cell lymphoma and follicular lymphoma at biopsy but HSIL by pap smear (Gynecol Oncol 2005;98:484)
- Three patients with atypical lymphoid cells at pap smear and diffuse large B cell lymphoma (Am J Hematol 2003;73:176)
Gross description
- Diffuse enlargement of cervix (barrel shaped), or polypoid mass with fish flesh appearance
- Soft, gray white
Microscopic (histologic) description
- Tumor cells infiltrate stroma without destroying glandular or squamous epithelium
Cytology description
- Round, loosely arranged neoplastic cells with scanty cytoplasm (Cytopathology 1996;7:204)
Cytology images
Images hosted on other servers:
Various Images
Differential diagnosis
- Chronic cervicitis: ThinPrep specimens may show clumps of lymphocytes (Cytopathology 2002;13:364)
- Granulocytic sarcoma: positive for myeloperoxidase, lysozyme, CD68, negative for lymphocytic markers
- Infectious mononucleosis or other reactive changes: polymorphic infiltrate with plasma cells and neutrophils (Gynecol Oncol 2005;99:481)
- Lymphoid follicles of chronic cervicitis
