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Cervix

Other epithelial tumors

Large cell neuroendocrine carcinoma

Last author update: 1 May 2007

Last staff update: 17 May 2021

Copyright: 2007-2024, PathologyOutlines.com, Inc.

PubMed Search: large cell neuroendocrine carcinoma [title] cervix

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Cite this page: Perunovic B. Large cell neuroendocrine carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixlargecellneuroendocrine.html. Accessed December 24th, 2024.

Definition / general

Rare ( < 1% of cervical carcinomas)
Mean age 34 years, range 21 to 62 years
Presents with abnormal Pap smear or vaginal bleeding
Aggressive behavior, similar to lung counterpart, with early metastases to regional lymph nodes and liver, lung, bone and brain (Int J Gynecol Pathol 2003;22:226)
Median survival < 2 years

Case reports

27 year old woman with 6 cm cervical mass (Case #327)
35 year old woman with small cell component (Gynecol Oncol 1998;68:69)
39 year old woman with carcinomatous meningitis (J Postgrad Med 2004;50:311)
Patient with HSIL (Pathology 1999;31:158)

Microscopic (histologic) description

Defined as moderate to severe nuclear atypia, neuroendocrine differentiation with cells larger than typical small cell carcinoma
Insular, trabecular, glandular and solid growth patterns
Usually eosinophilic cytoplasmic granules, > 10 MF/10 HPF and extensive necrosis
Angiolymphatic invasion
Often with adjacent adenocarcinoma in situ

Microscopic (histologic) images

Case #327