Pathology Outlines

Stains & CD markers
CD70-79

Last author update: 1 February 2002

Last staff update: 24 June 2021

Copyright: 2002-2024, PathologyOutlines.com, Inc.

PubMed Search: CD72[title], CD73[title], CD74[title], CD75, CD75s, CD77, CDw78

Table of Contents

CD70 | CD71 | CD72 | CD73 | CD74 | CD75 | CD75s / CDw76 | CD77 | CDw78 | CD79a | CD79b | Microscopic (histologic) images

Cite this page: Pernick N. CD70-79. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd70to79.html. Accessed December 22nd, 2024.

CD70

See CD70

CD71

See CD71

CD72

Cell surface protein expressed exclusively on B cells
Regulates mature B cell differentiation, prevents differentiation of naive B cells into plasma cells (Eur J Immunol 2005;35:2325)
Ligand of CD5 and CD100 (J Immunol 1992;148:1630, Int Immunol 2005;17:1277)
Not the same as DBA.44 (abstract in the following article is apparently wrong) (Am J Surg Pathol 1996;20:613)
Increased nucleotide mutation of CD72 mRNA accounts for decreased CD72 expression in B cells of teenage SLE patients (Pediatr Allergy Immunol 2006;17:565)
Uses by pathologists: marker of B cells (not commonly used)
Positive staining - normal: B cells only
Positive staining - disease: B cell lymphoma
Negative staining: plasma cells (Am J Hematol 1992;41:151)
Reference: OMIM: 107272 [Accessed 4 May 2021]

CD73

Also called ecto-5'-nucleotidase
Catalyzes dephosphorylation of ribo and deoxyribonucleotides to their corresponding nucleosides, such as 5’ AMP to adenosine
Mediates costimulatory signals in T cell activation
Mediates lymphocyte adhesion to dendritic cells and endothelium (Blood 1996;88:1755, J Immunol 2000;165:5411)
May protect against vascular inflammation and neointima formation (Circulation 2006;113:2120)
May be a lymphocyte maturation marker
No significant clinical use by pathologists
Positive staining - normal: B and T cell subset, endothelial cells, follicular dendritic cells and epithelial cells
Reference: OMIM: 129190 [Accessed 4 May 2021]

CD74

Also called LN2, HLA-DR associated invariant chain
Gamma chain antigen associated with MHC class II antigen and antigen presentation
MHC class II chaperone stabilizes alpha / beta heterodimers in a complex soon after synthesis and directs transport of the complex from the endoplasmic reticulum to compartments, where peptide loading of class II takes place
H. pylori urease binds to CD74 on gastric epithelial cells and upregulates CD74 expression (Infect Immun 2006;74:1148, J Immunol 2005;175:171)
Has important role in mucosal immunity
Receptor for macrophage migration inhibitory factor, a proinflammatory cytokine (J Immunol 2006;177:8730)
Associated with perineural invasion in pancreatic carcinoma (Clin Cancer Res 2006;12:2419)
Uses by pathologists: B cell marker (not commonly used)
Positive staining - normal: B cells, activated T cells, macrophages, interdigitating dendritic cells, activated endothelial and epithelial cells
Positive staining - disease:
- Many B cell lymphomas, myeloma (Clin Cancer Res 2004;10:6606)
- Some T cell lymphomas, Reed-Sternberg cells, many myeloid leukemias and Langerhans cell histiocytosis
- Renal clear cell and chromophobe carcinoma (most) (Am J Pathol 2001;158:1639)
Negatie staining: renal oncocytoma
Reference: OMIM: 142790 [Accessed 5 May 2021]

CD75

Also called lactosamines, LN1; formerly CDw75
Carbohydrate, not a protein (Cell 1992;68:1003)
Ligand for CD22 (Cell 1991;66:1133)
A neuraminidase sensitive lymphocyte cell surface differentiation antigen
Strong expression associated with better prognosis in follicular center cell lymphoma (J Pathol 2006;209:352)
Uses by pathologists: marker of follicular center cell lymphoma; identify Reed-Sternberg cells (not commonly used)
Positive staining - normal: mature B cells (germinal center derivation), erythrocytes, some T cells and some epithelial cells
Positive staining - disease: popcorn cells of lymphocyte predominance Hodgkin’s lymphoma, many B cell lymphomas (Histopathology 1999;35:209)
Reference: Arch Pathol Lab Med 2002;126:862

CD75s / CDw76

CDw76 renamed CD75s at 7th HLDA Workshop
Alpha 2, 6 sialylated lactosamines
A carbohydrate, not a protein
Marker of murine CD8+ suppressor T cells (Int Immunol 2003;15:1389)
No significant clinical use by pathologists
Positive staining - normal: B cells, some T cells

CD77

Also called globotriaosylceramide, CD77 synthase (OMIM: 607922 [Accessed 5 May 2021])
pK blood group antigen on erythrocytes
Carbohydrate, not a protein
Endothelial receptor for verotoxins from Shigella dysenteriae and E. coli (J Biol Chem 2006;281:10230)
Also expressed by liver flukes (Biol Chem 2001;382:195)
Interacts with CD19 (J Cell Physiol 1998;176:281)
Mediates apoptosis of renal vascular endothelial cells and intestinal epithelial cells, resulting in hemolytic uremic syndrome
Does not discriminate centroblasts from centrocytes
Uses by pathologists: identify germinal center cells
Positive staining - normal:
- B cells (centrocytes, centroblasts, plasmablasts) (J Immunol 2006;177:4341)
- Megakaryoblasts and platelets (J Biol Chem 2002;277:11247)
Positive staining - disease: Burkitt's lymphoma

CDw78

Deleted at 7th HLDA Workshop (reasons unknown)
Defines a conformation of MHC class II molecules bound to peptides acquired through trafficking to lysosomal antigen processing compartments and not MHC class II molecules associated with tetraspanins (J Immunol 2006;177:5451)
Appears on B cells following HLA-DR and preceding CD10, CD19, CD22 and CD37
No significant clinical use by pathologists
Positive staining - normal: B cells

CD79a

See CD79a

CD79b

See CD79b

Microscopic (histologic) images

Images hosted on other servers:

CD74: renal tumors (figs D-F)

CD74: multiple myelomas
(figs G-J)

CD74: increased expression in H. pylori+ epithelium

CD75: marginal zone lymphoma (aberrant expression)

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