Stains & CD markers
CD63
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD63
CD63
Author: Nat Pernick, M.D.
Last author update: 1 February 2002
Last staff update: 11 September 2023
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD63
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. CD63. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd63.html. Accessed November 27th, 2024.
Definition / general
- Also called NKI-C3 (J Natl Cancer Inst 1992;84:422), lysosomal membrane-associated glycoprotein 3, LAMP-3, melanoma associated antigen and ME491
- Member of tetraspanin superfamily of integral membrane proteins - tetraspanins form lateral associations with integrins and may act as organizers of multimolecular networks that modulate integrin mediated signaling, cell morphology, motility and migration
- Intracellular lysosomal / endosomal / granule protein, in Weibel-Palade bodies of endothelium and in azurophil granules of neutrophils (Am J Pathol 1994;144:1369)
- Serves as adaptor protein that links its interaction partners to the cell’s endocytic machinery (Proc Natl Acad Sci U S A 2003;100:15560)
- Marker of platelet activation that is transported to surface after activation; also modulates platelet spreading on immobilized fibrinogen (Thromb Haemost 2005;93:311)
- Associated with early stages of melanoma progression (Cancer Res 1988;48:2955)
- Deficiency associated with Hermansky-Pudlak syndrome (OMIM #203300)
- High pre-kidney transplant levels are associated with acute rejection (Transplant Proc 2003;35:1360)
- Used for basophil activation tests (Allergy 2006;61:1084)
- CD63 pathway from host multivesicular bodies provides essential lipids to Chlamydia to maintain productive intracellular infection (J Cell Sci 2006;119:350)
Uses by pathologists
- Marker of melanoma (although non-specific) and melanocytic tumors
- May be useful for other tumors (see below)
Microscopic (histologic) images
Images hosted on other servers:
Cellular neurothekeoma
Positive staining - normal
- Activated platelets, endothelium, fibroblasts, macrophages, mast cells and osteoclasts
- Weakly expressed on B and T cells and granulocytes
- Also bronchial glands, neural tissue (brain white matter and peripheral nerves), nevi, salivary glands, smooth muscle and synovial lining cells
Positive staining - disease
- Angiomyolipoma (100%) (Arch Pathol Lab Med 2001;125:751)
- Atypical fibroxanthoma (33%)
- Breast carcinoma (100%) (Am J Pathol 1998;153:973)
- Carcinoids (some)
- Cellular fibrous histiocytoma (50%)
- Cellular neurothekeoma (81%) (Mod Pathol 2004;17:230)
- Clear cell fibrous papule of nose (83%) (Am J Dermatopathol 2005;27:296)
- Deciduoid mesothelioma (67%) (Am J Surg Pathol 2000;24:285)
- Dermatofibrosarcoma protuberans (90%) (Am J Clin Pathol 1992;97:478)
- Histiocytic sarcoma
- Juvenile xanthogranuloma (60%)
- Melanoma (90%)
- Primitive nonneural granular cell tumors of skin (90%) (Am J Surg Pathol 2005;29:927)
- Renal oncocytoma (apical and polar staining)
- Renal chromophobe carcinoma-eosinophilic variant (diffuse staining) (Virchows Arch 2005;447:938)
- Reticulohistiocytoma (50%)
- Thyroid medullary carcinoma (some)
- Xanthoma (80%)
Negative staining
- Epithelioid cell histiocytoma, Langerhans cell histiocytosis
Additional references
