Stains & CD markers
CD57
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD57[title] CD Marker
CD57
Author: Nat Pernick, M.D.
Last author update: 1 February 2011
Last staff update: 2 July 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD57[title] CD Marker
Table of Contents
Definition / general | Case reports | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Positive staining - tumors | Negative stainingCite this page: Pernick N. CD57. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd57.html. Accessed November 27th, 2024.
Definition / general
- Also called Leu7, beta-1,3-glucuronyltransferase 1 and glucuronosyltransferase P
- Glycoprotein with cell adhesion functions
- May define a phenotype associated with replicative senescence in HIV specific CD8+ T cells (Blood 2003;101:2711)
- References: OMIM #151290
Case reports
- 6 year old girl with B-ALL, CD56 and CD57 coexpression (Pediatr Hematol Oncol 2004;21:677)
Uses by pathologists
- Marker of NK cells and neuroendocrine tumors, helps distinguish high grade prostatic adenocarcinoma (CD57+) from high grade urothelial carcinoma (CD57-)
Microscopic (histologic) images
Images hosted on other servers:
Large granular lymphocytic leukemia (fig 11)
Papillary carcinoma of thyroid (fig B)
"Atypical cytology, cannot exclude papillary carcinoma"
Positive staining - normal
- NK subset, T cell subset, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules
Positive staining - disease
- Leukemia / lymphomas: autoimmune lymphoproliferative syndrome, hepatosplenic T cell lymphoma (some), nodular lymphocyte predominant Hodgkin lymphoma (CD57+ rosettes in 50%, Am J Clin Pathol 2003;119:192), pre T-ALL (occasional) and T-cell large granular lymphocytic leukemia (some)
- Nerve sheath origin lesions: benign epithelioid nerve sheath tumor (Am J Surg Pathol 2005;29:39), chordoma, dendritic cell neurofibroma with pseudorosettes (Am J Surg Pathol 2001;25:587), melanotic neuroectodermal tumor of infancy, MPNST (expression decreases with tumor grade, Am J Surg Pathol 2003;27:1337) and nerve sheath myxoma (Am J Surg Pathol 2005;29:1615)
Positive staining - tumors
- Other: carcinoid tumors, desmoplastic nested spindle cell tumor of liver (Am J Surg Pathol 2005;29:1), desmoplastic small round cell tumor (Am J Surg Pathol 1998;22:1314), germ cell tumor (embryonal carcinoma, seminoma), mesenchymal chondrosarcoma, metanephric adenoma (Am J Surg Pathol 2001;25:1290), neuroendocrine carcinoma of prostate (Am J Surg Pathol 2006;30:684) and other sites, PNET, prostatic adenocarcinoma, renal carcinoid, renal clear cell carcinoma (some), small cell carcinoma of lung and other sites, spindle cell thymoma (Am J Surg Pathol 2001;25:111), synovial sarcoma and thyroid papillary carcinoma (Cancer 2006;108:331)
Negative staining
- B cells, monocytes, red blood cells and platelets; NK/T cell lymphoma-nasal type, Wilm’s tumor
