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Stains & CD markers
CD220-229

Nat Pernick, M.D.

Last author update: 1 January 2005
Last staff update: 24 June 2021

Copyright: 2003-2025, PathologyOutlines.com, Inc.

Nat Pernick, M.D.
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Table of Contents
CD220 | CD221 | CD222 | CD223 | CD224 | CD225 | CD226 | CD227 | CD228 | CD229
Cite this page: Pernick N. CD220-229. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd220to229.html. Accessed April 1st, 2025.
CD220
  • Aka insulin receptor
CD221
  • Aka insulin-like growth factor 1 receptor
  • Mediates insulin stimulated DNA synthesis and IGF1 stimulated cell proliferation and differentiation
  • Often overexpressed in malignant tissue, where it functions as an anti-apoptotic agent by enhancing cell survival
CD222
  • Aka insulin-like growth factor 2 receptor, mannose 6 phosphate receptor
  • Also a receptor for lysosomal hydrolases (i.e. assists in sorting lysosomal enzymes from Golgi apparatus or extracellular space to lysosomes)
CD223
  • Aka Lymphocyte-Activation Gene 3 (LAG-3)
  • Homologous to CD4
  • Associates with MHC class II molecules on monocytes/dendritic cells, which are subsequently activated
  • May help activated CD4+ and CD8+ T cells to fully activate monocytes and dendritic cells, leading to optimized MHC class I and class II T cell responses
  • Positive staining - normal: activated T cells, activated NK cells
CD224
  • Aka gamma-glutamyltransferase
  • Gene at 22q11.1-q11.2
  • Catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors, which maintains a homeostatic balance regarding oxidative stress
CD225
  • Aka Leu13, interferon-inducible transmembrane protein 1
  • Involved in relaying antiproliferative and homotypic adhesion signals
CD226
  • Aka DNAM-1, Platelet and T cell Activation antigen 1 (PTA1)
  • Mediates adhesion to an unknown ligand
  • T cell expression increased in some patients with autoimmune disease and viral infection
  • Positive staining - normal: NK cells, platelets, monocytes, subset of B and T cells
  • Negative staining: granulocytes, erythrocytes
CD227
CD228
  • Aka melanotransferrin
  • Cell surface glycoprotein found on melanoma cells, with sequence similarity and iron binding properties of transferrin superfamily
CD229
  • Aka Lymphocyte antigen 9
  • May be involved in adhesion between T cells and accessory cells
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