Cite this page: Pernick N. CD200-209. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd200.html. Accessed March 30th, 2025.
CD200
- Aka OX2
- An immunoadhesin that may deliver immunosuppressive signals and regulate autoimmune disorders
- Inhibitory for macrophage lineage cells
- Positive staining - normal: follicular dendritic cells, thymocytes, B cells, T cells, neurons, kidney glomeruli, syncytiotrophoblast, endothelial cells
CD201
- Binds protein C in a calcium-dependent manner
- Aka Endothelial Protein C Receptor (EPC R), protein C receptor
- Protein C is a vitamin K dependent enzyme with major role in coagulation of blood; activated when thrombin binds to thrombomodulin on endothelium.
- Mutations in CD201 and thrombomodulin associated with late fetal loss; similar mutation associated with venous thromboembolism and myocardial infarction
- Positive staining - normal: endothelial cells (not in liver and kidney)
CD202b
- Aka Tie2 (Tyrosine kinase with Ig-like loops and Epidermal growth factor homology domains), aka Tek
- Receptor tyrosine kinase at #9p21, binds to angiopoietin-1
- May be earliest mammalian endothelial cell lineage marker
- Involved in vein morphogenesis and communication between endothelial and smooth muscle cells for remodeling and repair of blood vessels
- Defects associated with inherited venous malformations
- Positive staining - normal: endothelial cells, hematopoietic cells
CD203c
CD204
CD205
CD206
CD207
- Aka langerin (Langerhans cell specific c-type lectin)
- Functions as endocytic receptor
- Localized to Birbeck granules
- Mannose binding to this protein may cause antigen internalization into Birbeck granules and access to a nonclassical antigen-processing pathway
- Positive staining - normal: Langerhans cells (immature dendritic cells of epidermis and mucosa)
CD208
